Methods for modifying electrical currents in neuronal circuits
First Claim
1. A method for modifying the electrical currents of a live neuronal circuit within the brain of a mammal, the method comprising the steps of:
- applying a focused ultrasound pulse (FUP) to the live neuronal circuit, where the applied FUP uses a low frequency to disrupt the neuronal circuits or a high frequency to activate the neuronal circuits;
and monitoring a brain image produced by a brain imaging system during the application of the FUP.
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Abstract
Disclosed herein are methods for modifying electrical currents in brain circuits through the simultaneous use of focused ultrasound pulse (FUP) and an existing brain-imaging system, such as a functional magnetic resonance imaging (fMRI) system. The methods are used for research, treatment and diagnosis of psychiatric, neurological, and neuroendocrine disorders whose biological mechanisms include brain circuits. The methods include the simultaneous steps of applying FUP to a live neuronal circuit within a brain and monitoring a brain image produced by a brain imaging system during the application of FUP.
78 Citations
36 Claims
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1. A method for modifying the electrical currents of a live neuronal circuit within the brain of a mammal, the method comprising the steps of:
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applying a focused ultrasound pulse (FUP) to the live neuronal circuit, where the applied FUP uses a low frequency to disrupt the neuronal circuits or a high frequency to activate the neuronal circuits; and monitoring a brain image produced by a brain imaging system during the application of the FUP. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of treating psychiatric, neurological and neuroendocrine disorders in a mammal, the method comprising the steps of:
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applying a focused ultrasound pulse (FUP) to the live neuronal circuit, where the applied FUP uses a low frequency to disrupt the neuronal circuits or a high frequency to activate the neuronal circuits; and monitoring a brain image from a brain imaging system during the application of the FUP. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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Specification