Monitoring and synchronizing ventricular contractions using an implantable stimulation device

• US 7,283,873 B1
• Filed: 05/03/2004
• Issued: 10/16/2007
• Est. Priority Date: 05/03/2004
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Bornzin, Gene A., Park, Euljoon
• Primary Examiner(s): Layno; Carl
• Assistant Examiner(s): Gedeon; Brian T.
• Application Number:
  US10/838,692
• Time in Patent Office: 1,261 Days
• Field of Search: 600/486, 607 17- 19
• US Class Current: 607/16
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

An implantable cardiac stimulation device is configured to measure selected ventricular contraction parameters and apply stimulation therapy based on an analysis of the ventricular contraction parameters. The ventricular contraction parameters may include impedance values that correspond to the volume of fluid in the right ventricle and the left ventricle. The ventricular contraction parameters may include motion values that correspond to heart sounds/motion in the right ventricle and the left ventricle. The ventricular contraction parameters can be used to form a ventricular parameter loop associated with one or more cardiac cycles. The total area within the resulting loop should be maintained below a threshold value through the application of applicable stimulation therapy and/or further physician assistance.

Claims

1. In an implantable cardiac stimulation device, a method comprising:

collecting a plurality of right ventricle (RV) contraction parameters during at least one cardiac cycle;

collecting a plurality of left ventricle (LV) contraction parameters during said at least one cardiac cycle, without using a LV pressure sensor, wherein said plurality of LV contraction parameters includes a plurality of LV impedance values and collecting said plurality of LV contraction parameters includes measuring said plurality of LV impedance values using a first electrode having at least one electrical contact within the right ventricle, and a second electrode associated with said left ventricle, said second electrode having at least one electrical contact with cardiac tissue of said left ventricle, said first and second electrodes operatively arranged to pass an electrical signal on a path that includes blood within a chamber of the left ventricle; and

processing said RV contraction parameters as a function of said LV contraction parameters to produce data corresponding to an RV-LV contraction loop.

2. The method as recited in claim 1, further comprising:

with the implantable cardiac stimulation device, applying stimulation therapy to at least one ventricle based on said data corresponding to an RV-LV contraction loop.

3. The method as recited in claim 1, further comprising:

causing the implantable cardiac stimulation device to output said data corresponding to an RV-LV contraction loop to at least one external device.

4. The method as recited in claim 1, wherein processing said RV and LV contraction parameters to produce said data corresponding to an RV-LV contraction loop further includes:

determining an area value as defined by said data corresponding to an RV-LV contraction loop for said at least one cardiac cycle.

5. The method as recited in claim 4, further comprising:

with the implantable cardiac stimulation device, applying stimulation therapy to at least one ventricle based on said ventricular contraction loop data to improve efficiency of pumping contractions of the RV and LV.

6. The method as recited in claim 5, further comprising:

adjusting said stimulation therapy such that subsequent area values fall within a predetermined range of acceptable area values.

7. The method as recited in claim 4, further comprising:

causing the implantable cardiac stimulation device to output said area value to at least one external device.

8. The method as recited in claim 7, further comprising:

monitoring area values during a period that includes a plurality of cardiac cycles; and

alerting said external device if said monitoring determines that said area data is not within a predefined range of acceptable area values.

9. The method as recited in claim 1, wherein said plurality of RV contraction parameters includes a plurality of RV impedance values and collecting said plurality of RV contraction parameters includes:

measuring said plurality of RV impedance values using at least two electrodes that are operatively arranged to pass an electrical signal on a path that includes blood within a chamber of the right ventricle.

10. The method as recited in claim 9, wherein said at least two electrodes includes a first electrode having at least one electrical contact within the right ventricle, and a second electrode associated with a case of the implantable cardiac stimulation device.

11. The method as recited in claim 9, wherein measuring each of said plurality of RV impedance values further includes:

passing said electrical signal, having a known current value between said at least two electrodes;

measuring a voltage value for said electrical signal that has passed through intervening tissue and liquids; and

dividing said measured voltage value by said known current value to produce a measured RV impedance value.

12. The method as recited in claim 1, wherein measuring each of said plurality of LV impedance values further includes:

passing said electrical signal, having a known current value between said at least two electrodes;

measuring a voltage value for said electrical signal that has passed through intervening tissue and liquids; and

dividing said measured voltage value by said known current value to produce a measured LV impedance value.

13. The method as recited in claim 1, wherein said plurality of RV contraction parameters includes a plurality of RV motion values and collecting said plurality of RV contraction parameters includes:

measuring said plurality of RV motion values using at least one lead that is operatively arranged within a chamber of said RV and responsive to physical motion effecting said chamber.

14. The method as recited in claim 13, wherein said at least one lead includes at least one accelerometer.

15. An implantable cardiac stimulation device comprising:

means for collecting a plurality of right ventricle (RV) contraction parameters during at least one cardiac cycle;

means for collecting a plurality of left ventricle (LV) contraction parameters during said at least one cardiac cycle, without using a LV pressure sensor, wherein said plurality of LV contraction parameters includes a plurality of LV impedance values and said means for collecting a plurality of LV contraction parameters includes a first electrode having at least one electrical contact within the right ventricle, and a second electrode associated with said left ventricle, said second electrode having at least one electrical contact with cardiac tissue of said left ventricle, said first and second electrodes operatively arranged to pass an electrical signal on a path that includes blood within a chamber of the left ventricle; and

means for processing said RV contraction parameters as a function of said LV contraction parameters to produce data corresponding to an RV-LV contraction loop.

16. The implantable cardiac stimulation device as recited in claim 15, further comprising:

means for applying stimulation therapy to at least one ventricle based on said data corresponding to an RV-LV contraction loop.

17. The implantable cardiac stimulation device as recited in claim 15, further comprising:

means for causing the implantable cardiac stimulation device to output said data corresponding to an RV-LV contraction loop to at least one external device.

18. The implantable cardiac stimulation device as recited in claim 17, further comprising:

means for determining an area value as defined by said data corresponding to an RV-LV contraction loop for said at least one cardiac cycle.

19. The implantable cardiac stimulation device as recited in claim 18, further comprising:

means for applying stimulation therapy to at least one ventricle based on said data corresponding to an RV-LV contraction loop to improve efficiency of pumping contractions of the RV and LV.

20. The implantable cardiac stimulation device as recited in claim 18, further comprising:

means for adjusting said stimulation therapy such that subsequent area values fall within a predetermined range of acceptable area values.

21. The implantable cardiac stimulation device as recited in claim 18, further comprising:

means for outputting said area value to at least one external device.

22. The implantable cardiac stimulation device as recited in claim 21, further comprising:

means for monitoring area values during a period that includes a plurality of cardiac cycles; and

means for alerting said external device if said monitoring determines that said area data is not within a predefined range of acceptable area values.

23. The implantable cardiac stimulation device as recited in claim 15, wherein said plurality of RV contraction parameters includes a plurality of RV impedance values and further comprising:

means for measuring said plurality of RV impedance values using at least two leads that are operatively arranged to pass an electrical signal on a path that includes blood within a chamber of the right ventricle.

24. An implantable cardiac stimulation device comprising:

memory;

input/output (I/O) circuitry configurable to make electrical contact with tissue within a patient and exchange information with at least one external device, said I/O circuitry including a first electrode having at least one electrical contact within the right ventricle, and a second electrode associated with said left ventricle, said second electrode having at least one electrical contact with cardiac tissue of said left ventricle, said first and second electrodes operatively arranged to pass an electrical signal on a path that includes blood within a chamber of the left ventricle; and

logic operatively coupled to said memory and said I/O circuitry, said logic being configured to collect right ventricle (RV) contraction parameters and left ventricle (LV) contraction parameters from said I/O circuitry, process said RV contraction parameters as a function of said LV contraction parameters to produce data corresponding to an RV-LV contraction loop, and store at least a portion of said data corresponding to an RV-LV contraction loop in said memory, and wherein said RV and LV contraction parameters are collected during at least one cardiac cycle, said portion of said I/O circuitry does not include a lead within a chamber of the left ventricle, and said LV contraction parameters include a plurality of LV impedance values.

25. The implantable cardiac stimulation device as recited in claim 24, wherein said logic is further configured to cause said I/O circuitry to apply stimulation therapy to at least one ventricle based on said data corresponding to an RV-LV contraction loop.

26. The implantable cardiac stimulation device as recited in claim 24, wherein said logic is further configured to cause said I/O circuitry to output said data corresponding to an RV-LV contraction loop to said at least one external device.

27. The implantable cardiac stimulation device as recited in claim 24, wherein said logic is further configured to determine an area value as defined by said data corresponding to an RV-LV contraction loop for said at least one cardiac cycle.

28. The implantable cardiac stimulation device as recited in claim 27, wherein said logic is further configured to cause said I/O circuitry to apply stimulation therapy to at least one ventricle based on at least one said area value to improve efficiency of pumping contractions of the RV and LV.

29. The implantable cardiac stimulation device as recited in claim 28, wherein said logic is further configured to adjusting said stimulation therapy such that subsequent area values fall within a predetermined range of acceptable area values.

30. The implantable cardiac stimulation device as recited in claim 27, wherein said logic is further configured to cause said I/O circuitry to output said area value to said at least one external device.

31. The implantable cardiac stimulation device as recited in claim 27, wherein said logic is further configured to monitor area values during a period that includes a plurality of cardiac cycles, and alert said external device if said area data is not within a predefined range of acceptable area values.

32. The implantable cardiac stimulation device as recited in claim 24, wherein said RV contraction parameters includes a plurality of RV impedance values and said I/O circuitry includes:

at least two leads that can be operatively arranged to pass an electrical signal on a path that includes blood within a chamber of the right ventricle and said I/O circuitry is configurable to measure said plurality of RV impedance values using said at least two leads and provide said RV impedance values to said logic.