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Method of measuring neural responses

  • US 7,283,877 B1
  • Filed: 12/19/2003
  • Issued: 10/16/2007
  • Est. Priority Date: 12/20/2002
  • Status: Active Grant
First Claim
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1. A method of recording and processing neural response (NR), the method comprising:

  • (a) providing a stimulating electrode, E1, and a stimulating electrode, E2, and a recording electrode ER;

    (b) recording RC, in response to a combination of a first, sub-threshold stimulus pulse, S1 at E1, having amplitude A and a second, sub-threshold stimulus pulse, S2 at E2, having amplitude B, wherein S1 and S2 are applied simultaneously and, when added together, provide a supra-threshold stimulus amplitude C;

    (c) recording R1, in response to a sub-threshold stimulus pulse, S1 delivered through electrode E1;

    (d) recording R2, in response to a sub-threshold stimulus pulse, S2 delivered through electrode E2;

    (e) recording R0, in response to no stimulation at any stimulating electrodes; and

    (f) processing the recordings to yield an estimated NR in accordance with the relation;

    NR=RC−

    (R1+R2)+R0, wherein the steps (b), (c), (d) and (e) may be performed in any order.

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