Brain stimulation lead used for lesioning

• US 7,285,118 B1
• Filed: 07/18/2003
• Issued: 10/23/2007
• Est. Priority Date: 07/18/2002
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation), Functional Neuroscience Inc.
• Original Assignee: Functional Neuroscience Inc.
• Inventors: Lozano, Andres M.
• Primary Examiner(s): PEFFLEY, MICHAEL F
• Application Number:
  US10/622,227
• Time in Patent Office: 1,558 Days
• Field of Search: 607/115, 607/116, 607/117, 607/122, 607/123, 607/148, 600/372, 600/373, 600/393, 600/378, 128/898
• US Class Current: 606/41
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2018/00446 Brain
• CPC Class Codes: A61B 2018/00791 Temperature
• CPC Class Codes: A61B 2018/1467 using more than two electrodes on a single probe
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/06 for high-frequency therapy

Abstract

A brain stimulation lead such as a deep brain stimulation (DBS) lead is provided, which lead can also be used to create lesions safely and effectively due to inclusion of temperature sensing. The generating of radio-frequency (RF) lesions via a brain stimulation lead provides a new treatment option, for instance, when hardware-related or other complications necessitate lead removal. An existing implanted DBS lead was used to create lesions in the thalamus and subthalamus of patients with movement disorders. Various brain stimulation leads with temperature sensors are described. Various methods are disclosed, including creation of a lesion with a brain stimulation lead while sensing temperature with a sensor implanted as part of the lead or with a noninvasive sensing device. Another method includes creating a graduated lesion with a brain stimulation lead of the invention or with a chronic lesioning lead.

Claims

1. A method for creating a lesion in a patient'"'"'s body, comprising:

a) implanting a lead in a patients brain;

b) electrically connecting the lead to an external RF generator;

c) creating a lesion with the lead and the external RF generator;

d) disconnecting the lead from the external RF generator;

e) waiting at least one week;

f) evaluating the results of the lesion; and

g) repeating b) through f) at least once to create a progressive, graduated lesion.

2. The method of claim 1 further comprising connecting the lead to a pulse generating device and delivering stimulating pulses to the patient'"'"'s brain with the lead and the pulse generating device.

3. The method of claim 1 further comprising removing the lead from the patient'"'"'s brain.

4. The method of claim 1 further comprising creating the lesion outside the operating room.

5. The method of claim 1 wherein electrically connecting to and disconnecting the lead from the external RF generator comprises electrically connecting and disconnecting transcutaneously.

6. The method of claim 5 further comprising an RF coil coupled to the lead that is inductively coupled to the external RF generator.

7. The method of claim 1 wherein the lesion is created in response to a hardware complication requiring hardware revision or removal of one or more components of a brain stimulation system.

8. The method of claim 7 wherein the hardware complication comprises at least one of infection, erosion, fracture, migration, short-circuit, and physical disconnection of one or more components of a brain stimulation system.

9. The method of claim 1 wherein the lesion is created in response to the patient developing a tolerance to brain stimulation.

10. The method of claim 2 wherein the lesion is created in response to the patient developing a tolerance to brain stimulation.

11. The method of claim 1 wherein the lesion is created in response to failure of a battery in a brain stimulation system.

12. The method of claim 1 wherein the lesion is created in response to a need for frequent battery replacements in a brain stimulation system.

13. The method of claim 1 wherein the lesion is created in response to a need for progressively increasing current output from a brain stimulation system.

14. The method of claim 1 wherein the progressive, graduated lesion is created as an alternative to using brain stimulation.

15. The method of claim 1 wherein the progressive, graduated lesion is created as an addition to delivering stimulating pulses to the patient'"'"'s brain with a pulse generating device.

16. The method of claim 15 wherein the progressive, graduated lesion is created prior to initiation or resumption of stimulation.

17. The method of claim 16 wherein the progressive, graduated lesion decreases the current delivery requirements of stimulation.

18. The method of claim 16 wherein the progressive, graduated lesion prolongs battery life of the pulse generating device.

19. The method of claim 2 wherein the progressive, graduated lesion prolongs battery life of the pulse generating device.