Method of making a housing for drug delivery

• US 7,287,319 B2
• Filed: 04/07/2005
• Issued: 10/30/2007
• Est. Priority Date: 12/19/2001
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Kleiner, Lothar W., Young, Wendy A.
• Primary Examiner(s): Arbes; Carl J.
• Application Number:
  US11/101,844
• Publication Number:
  US 20050193554A1
• Time in Patent Office: 936 Days
• Field of Search: 298/25, 298/74, 604/20
• US Class Current: 29/825
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: Y10T 29/49082 Resistor making
• CPC Class Codes: Y10T 29/49117 Conductor or circuit manufacturing
• CPC Class Codes: Y10T 29/49128 Assembling formed circuit to base
• CPC Class Codes: Y10T 29/4913 Assembling to base an electrical component, e.g., capacitor, etc.
• CPC Class Codes: Y10T 29/49155 Manufacturing circuit on or in base
• CPC Class Codes: Y10T 29/49204 Contact or terminal manufacturing

Abstract

An electrotransport reservoir housing which contains, integrally formed therein, at least one region of conductive material which allows for a liquid and moisture tight barrier, while at the same time providing a means for conducting an electric current therethrough.

Claims

1. A method of making an integral reservoir housing for an iontophoretic drug delivery device comprising the steps of:

providing a sheet of material containing at least one region of conductive material and at least one region of non-conductive material;

said conductive and non-conductive regions forming at least one interface where said conductive and non-conductive material meet, and the sheet of material including a planar surface portion that includes a conductive surface portion and a nonconductive surface portion;

forming a reservoir blank out of said sheet of material, said reservoir blank having at least one conductive region and at least one non-conductive region;

forming a first cavity in said reservoir blank, said first cavity at least partially formed out of a conductive region of said reservoir blank;

forming a second cavity in the sheet of material; and

wherein said first cavity and said second cavity are separated by at least one region of non-conductive material.

2. The method of claim 1, wherein said second cavity is at least partially formed out of a region of conductive material of the reservoir blank, other than the regions used to form said first cavity.

3. The method of claim 2, wherein said conductive material in said sheet of material comprises a polymer.

4. The method of claim 2, comprising forming the sheet of material by extrusion.

5. The method of claim 2, comprising coextruding at least three strips of materials to form the sheet of material, the at least three strips of materials including conductive strip and nonconductive strip.

6. The method of claim 2, comprising coextruding at least two strips of materials in a coplanar manner to form the sheet of material, the at least two strips of materials including conductive strip and nonconductive strip.

7. A method of making an integral reservoir housing for an iontophoretic drug delivery device comprising the steps of:

providing a sheet of material comprising one region of non-conductive material having a first side and a second side, said sheet of material further comprising a first and a second region of conductive material, said first conductive region disposed in contact with said first side of said non-conductive material and said second conductive region disposed in contact with said second side of said non-conductive material;

said conductive and non-conductive regions forming at least one interface where said conductive and non-conductive material meet, and the sheet of material including a planar surface portion that includes a conductive surface portion and a nonconductive surface portion;

forming a reservoir blank out of said sheet of material, said reservoir blank having at least one conductive region and at least one non-conductive region;

forming a first cavity in said reservoir blank, said first cavity at least partially formed out of a conductive region of said reservoir blank;

forming a second cavity in said reservoir blank; and

wherein all conductive regions are separated from each other by non-conductive regions.

8. A method of making an integral reservoir housing for an iontophoretic drug delivery device comprising the steps of:

providing a sheet of material comprising a first and a second separate region of conductive material, each having a first end and a second end, said conductive regions separated by a first region of non-conductive material disposed so as to be in contact with the second end of each of said regions of conductive material, said sheet of material further comprising a second and a third region of non-conductive material, wherein said second non-conductive region is disposed at the first end of said first region of conductive material and said third region of non-conductive material is disposed at said first end of said second region of conductive material;

said conductive and non-conductive regions forming at least one interface where said conductive and non-conductive material meet, and the sheet of material including a planar surface portion that includes a conductive surface portion and a nonconductive surface portion;

forming a reservoir blank out of said sheet of material, said reservoir blank having at least one conductive region and at least one non-conductive region;

forming a first cavity in said reservoir blank, said first cavity at least partially formed out of a conductive region of said reservoir blank;

forming a second cavity in said reservoir blank; and

wherein all conductive regions are separated from each other by non-conductive regions.

9. A method of making an integral reservoir housing for an iontophoretic drug delivery device comprising the steps of:

providing a sheet of material comprising one region of non-conductive material having a first side and a second side, said sheet of material further comprising a first and a second region of partially conductive material, said partially conductive material comprised of at least one region of conductive material and one region of non-conductive material, said first partially conductive region disposed at said first side of said non-conductive material and said second partially conductive region disposed at said second side of said non-conductive material, and the sheet of material including a planar surface portion that includes a conductive surface portion and a nonconductive surface portion;

forming a reservoir blank out of said sheet of material, said reservoir blank having at least one conductive region and at least one non-conductive region;

forming a first cavity in said reservoir blank, said first cavity at least partially formed out of a conductive region of said reservoir blank;

forming a second cavity in said reservoir blank; and

wherein all conductive regions are separated from each other by non-conductive regions.

10. A method of making an integral reservoir housing for an iontophoretic drug delivery device comprising the steps of:

providing a sheet of material comprising one region of non-conductive material having a first side and a second side, said sheet of material further comprising a first and a second region of partially conductive material, said partially conductive material comprised of at least one region of conductive material and one region of non-conductive material, said first partially conductive region disposed at said first side of said non-conductive material and said second partially conductive region disposed at said second side of said non-conductive material, and the sheet of material including a planar surface portion that includes a conductive surface portion and a nonconductive surface portion;

forming a reservoir blank out of said sheet of material, said reservoir blank having at least one conductive region and at least one non-conductive region;

forming a first cavity in said reservoir blank, said first cavity being completely formed out of a conductive region of said reservoir blank;

forming a second cavity in said reservoir blank; and

wherein all conductive regions are separated from each other by non-conductive regions.

11. A method of making an integral reservoir housing for an iontophoretic drug delivery device comprising the steps of:

providing a sheet of material containing at least one region of conductive material and at least one region of non-conductive material;

said conductive and non-conductive regions forming at least one interface where said conductive and non-conductive material meet to result in a joint between a conductive surface portion and a nonconductive surface portion, said interface not on the same plane as said conductive surface portion or said nonconductive surface portion;

forming a reservoir blank out of said sheet of material, said reservoir blank having at least one conductive region and at least one non-conductive region;

forming a first cavity in said reservoir blank, said first cavity at least partially formed out of a portion of one of said conductive regions of said reservoir blank;

forming a second cavity in said reservoir blank; and

wherein all conductive regions are separated from each other by non-conductive regions.

12. A method of making an integral reservoir housing for an iontophoretic drug delivery device comprising the steps of:

providing a sheet of material containing at least one region of conductive material and at least one region of non-conductive material;

said conductive and non-conductive regions forming at least one interface where said conductive and non-conductive material meet, and the sheet of material including a planar surface portion that includes a conductive surface portion and a nonconductive surface portion;

forming a reservoir blank out of said sheet of material, said reservoir blank having at least one conductive region and at least one non-conductive region;

forming a first cavity in said reservoir blank, said first cavity at least partially formed out of a conductive region of said reservoir blank;

all conductive regions being separated from each other by non-conductive regions;

forming a second cavity in said reservoir blank; and

wherein said interface is liquid and vapor tight.

13. A method of making an integral reservoir housing for an iontophoretic drug delivery device comprising the steps of:

providing a sheet of material containing at least one region of conductive material and at least one region of non-conductive material;

said conductive and non-conductive regions forming at least one interface where said conductive and non-conductive material meet, and the sheet of material including a planar surface portion that includes a conductive surface portion and a nonconductive surface portion;

forming a reservoir blank out of said sheet of material, said reservoir blank having at least one conductive region and at least one non-conductive region;

forming a first cavity in said reservoir blank, said first cavity at least partially formed out of a conductive region of said reservoir blank;

all conductive regions being separated from each other by non-conductive regions;

forming a second cavity in said reservoir blank; and

wherein said sheet of material is comprised of a polymer selected from the group consisting of polyvinyl chloride, polyethylene terephthalate glycol, polyethylene, polypropylene, polycarbonate, and acrylics.