Contact-killing antimicrobial devices

• US 7,288,264 B1
• Filed: 07/17/2000
• Issued: 10/30/2007
• Est. Priority Date: 12/20/1993
• Status: Expired due to Fees

• Current Assignee: Surfacine Development Company LLC
• Original Assignee: Surfacine Development Company LLC
• Inventors: Shalon, Tadmor, Sawan, Samuel P., Yurkovetskiy, Alexander, Subramanyam, Sundar
• Primary Examiner(s): Levy; Neil S.
• Application Number:
  US09/617,566
• Time in Patent Office: 2,661 Days
• Field of Search: 424/402, 424/404, 424/405, 424/407, 424/409, 424411-415, 424/422, 424/430, 424/78.17, 424/618, 424/630, 514/495, 514/499, 523/122, 600/466, 600/467, 604/264, 604/265, 604/508
• US Class Current: 424/404
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof

Abstract

Contact killing antimicrobial articles, devices and formulations are described which kill microorganisms on contact. The articles, devices or formulations contain a non-leaching antimicrobial material which is a unique combination of an organic matrix having biocidal metallic materials non-leachably associated with the matrix. The antimicrobial material may used to form an antimicrobial coating or layer on a surface of the article or device, or may be dispersed in a vehicle or carrier to form a topical antiseptic or disinfectant, or solid shape having contact killing antimicrobial properties. When a microorganism contacts the article, device, or formulation, the biocidal metallic material is transferred to the microorganism in amounts sufficient to kill it.

Claims

1. An article of manufacture comprising an adherent antimicrobial coating comprising a nitrogen-containing polycationic polymer matrix immobilized on a surface of the article of manufacture, and an antimicrobial metallic material bound to the matrix such that the antimicrobial coating does not release biocidal amounts of elutables into the surrounding ambient liquid for at least 5 days.

2. The article of claim 1 wherein the nitrogen-containing polycationic polymer matrix comprises benzalkonium groups.

3. The article of claim 1 wherein the antimicrobial metallic material is selected from the group consisting of a metal, a metal salt, a metal complex, a metal alloy, and mixtures thereof.

4. The article of claim 3 wherein the metallic material comprises silver.

5. The article of claim 3 wherein the mixture comprises silver and copper.

6. The article of claim 3 wherein the metal salt is silver iodide.

7. The article of claim 1 wherein the nitrogen-containing polycationic polymer matrix is crosslinked with a crosslinking agent.

8. The article of claim 7, wherein the crosslinking agent is selected from the group consisting of isocyanates, carboxylic acids, acid chlorides, acid anhydrides, succinimidyl ether aldehydes, ketones, alkyl methanesulfonates, alkyl trifluoromethanesulfonates, alkyl para-toluenemethanesulfonates, alkyl halides, and epoxides.

9. The article of claim 7 wherein the crosslinking agent is N,N-methylene-bis-diglycidylaniline.

10. The article of claim 1 wherein the article is a medical device, a personal care product, or a consumer product.

11. The article of claim 1 wherein the article is a medical device selected from the group consisting of surgical gloves, surgical instruments, dental care instruments, dental consoles, instrument trays, catheters, urological devices, blood collection and transferring devices, devices from for implanting in a patient, urine collection devices, ophthalmic devices, intraocular lenses, tracheotomy devices, topical disinfectants and wound dressings.

12. The article of claim 10 wherein the personal care product is selected from the group consisting of hair care items, toothbrushes, dental floss, dental implements, contact lenses, contact lens storage cases, baby care items, child care items, bathroom implements, bed linens, towels and washcloths.

13. The article of claim 10, wherein the consumer product is selected from the group consisting of kitchen implements, trash containers, disposable trash bags and cutting boards.

14. The article of manufacture of claim 1, wherein the antimicrobial coating is immobilized on the surface by covalent bonding, ionic interaction, coulombic interaction, hydrogen bonding, or crosslinking.

15. The article of manufacture of claim 1, wherein the antimicrobial coating is immobilized on the surface via a functional group of the nitrogen-containing polycationic polymer.

16. The article of manufacture of claim 1, wherein the functional group selected from the group consisting of a thiol group, a hydroxy group, an amine group, a halogen, an epoxy group, an alkyl group, and an alkoxy group.

17. An article of manufacture comprising an adherent antimicrobial coating comprising a nitrogen-containing polycationic polymer matrix immobilized on a surface of the article of manufacture by covalent bonding, ionic interaction, coulombic interaction, hydrogen bonding, or cross-linking, and

an antimicrobial metallic material bound or attached to the matrix such that the antimicrobial coating does not release biocidal amounts of elutables into the surrounding ambient liquid for at least 5 days.

18. An article of manufacture comprising an adherent antimicrobial coating comprising a nitrogen-containing polycationic polymer matrix immobilized on a surface of the article of manufacture, the nitrogen-containing polycationic polymer matrix being functionalized to enable immobilization on the surface, and

an antimicrobial metallic material bound to the matrix such that the antimicrobial coating does not release biocidal amounts of elutables into the surrounding ambient liquid for at least 5 days.

19. The article of manufacture of claim 18, wherein the nitrogen-containing polycationic polymer is functionalized with a thiol group, a hydroxy group, an amine group, a halogen, an epoxy group, an alkyl group, an alkoxy group, and mixtures thereof.