Multivariate analysis of green to ultraviolet spectra of cell and tissue samples
First Claim
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1. A method for processing in vivo skin auto fluorescence spectra emitted by a skin surface of a patient to determine a blood glucose level of the patient comprising the steps of:
- collecting clinical fluorescence spectra data and corresponding glucose values from a range of individuals, said spectra data responsive to irradiation of tissue at a plurality of wavelengths of energy;
sorting said clinical fluorescence spectra data according to said glucose values;
processing said sorted clinical fluorescence spectra data to reduce effects of noise;
collecting fluorescence spectra data emitted from the skin surface of the patient;
correcting the collected spectra data using multivariate analysis to account for skin surface variables; and
determining a blood glucose level of the patient based on at least said corrected spectra data and said processed clinical fluorescence spectra data.
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Abstract
This invention relates to methods for processing in vivo skin auto-fluorescence spectra for determining blood glucose levels. The invention also relates to methods of classifying cells or tissue samples or quantifying a component of a cell or tissue using a multivariate classification or quantification model.
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2 Claims
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1. A method for processing in vivo skin auto fluorescence spectra emitted by a skin surface of a patient to determine a blood glucose level of the patient comprising the steps of:
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collecting clinical fluorescence spectra data and corresponding glucose values from a range of individuals, said spectra data responsive to irradiation of tissue at a plurality of wavelengths of energy; sorting said clinical fluorescence spectra data according to said glucose values; processing said sorted clinical fluorescence spectra data to reduce effects of noise; collecting fluorescence spectra data emitted from the skin surface of the patient; correcting the collected spectra data using multivariate analysis to account for skin surface variables; and determining a blood glucose level of the patient based on at least said corrected spectra data and said processed clinical fluorescence spectra data. - View Dependent Claims (2)
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