Hemofiltration methods for treatment of diseases in a mammal
First Claim
1. A method for treating a disease in a mammal comprising:
- pumping blood from the mammal using a blood pump;
transferring the blood from the blood pump to a hemofilter;
removing an ultrafiltrate from the blood using the hemofilter to create a filtered blood stream and an ultrafiltrate stream;
transferring the ultrafiltrate stream from the hemofilter to an adsorptive device containing at least one fixed adsorbent material;
selectively removing an inflammatory mediator which causes Compensatory Anti-inflammatory Response Syndrome from the ultrafiltrate stream using the adsorbent material to create a post adsorption ultrafiltrate stream;
combining at least a portion of the post adsorption ultrafiltrate stream with the filtered blood stream and returning the combined post adsorption ultrafiltrate stream and the filtered blood stream to the mammal;
transferring a portion of the post adsorption ultrafiltrate stream which is not returned to the mammal to a waste reservoir; and
providing at least one therapeutic agent to the blood.
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Accused Products
Abstract
A hemofiltration system and method to treat an Inflammatory Mediator Related Disease in a mammal, including chronic and acute diseases, include a hemofilter and an adsorptive device. The hemofilter removes ultrafiltrate from a blood stream extracted from the mammal to create a filtered blood stream and an ultrafiltrate stream. The adsorptive device may include one or more adsorbent materials and may be used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilter to create a post adsorption ultrafiltrate stream. The post adsorption ultrafiltrate stream may be selectively combined with the filtered blood stream and together with the filtered blood stream may be returned to the mammal.
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Citations
21 Claims
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1. A method for treating a disease in a mammal comprising:
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pumping blood from the mammal using a blood pump; transferring the blood from the blood pump to a hemofilter; removing an ultrafiltrate from the blood using the hemofilter to create a filtered blood stream and an ultrafiltrate stream; transferring the ultrafiltrate stream from the hemofilter to an adsorptive device containing at least one fixed adsorbent material; selectively removing an inflammatory mediator which causes Compensatory Anti-inflammatory Response Syndrome from the ultrafiltrate stream using the adsorbent material to create a post adsorption ultrafiltrate stream; combining at least a portion of the post adsorption ultrafiltrate stream with the filtered blood stream and returning the combined post adsorption ultrafiltrate stream and the filtered blood stream to the mammal; transferring a portion of the post adsorption ultrafiltrate stream which is not returned to the mammal to a waste reservoir; and providing at least one therapeutic agent to the blood. - View Dependent Claims (2, 3, 4)
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5. A method for treating Compensatory Anti-inflammatory Response Syndrome in a mammal comprising:
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performing hemofiltration on blood from the mammal using a hemofilter to generate an ultrafiltrate; transferring the ultrafiltrate to an adsorptive device containing at least one fixed adsorbent material; selectively removing an inflammatory mediator which causes Compensatory Anti-inflammatory Response Syndrome from the ultrafiltrate using the adsorbent material to create a post adsorption ultrafiltrate; returning at least a portion of the post adsorption ultrafiltrate to the mammal; and providing at least one therapeutic agent to the blood. - View Dependent Claims (6, 7, 8, 9, 10, 11)
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12. A method for treating Compensatory Anti-inflammatory Response Syndrome in a mammal comprising:
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receiving blood from the mammal; filtering the blood using a hemofilter to remove an inflammatory mediator from the blood; and providing at least one biological therapeutic agent to the blood to reduce adverse inflammatory mediator effects associated with treating Compensatory Anti-inflammatory Response Syndrome.
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13. A method for treating a disease in a mammal comprising:
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pumping blood from the mammal using a blood pump; transferring the blood from the blood pump to a hemofilter; removing an ultrafiltrate from the blood using the hemofilter to create a filtered blood stream and an ultrafiltrate stream; transferring the ultrafiltrate stream from the hemofilter to an adsorptive device containing at least one fixed adsorbent material; selectively removing an inflammatory mediator which causes an Inflammatory Mediator Related Disease from the ultrafiltrate stream using the adsorbent material to create a post adsorption ultrafiltrate stream; combining at least a portion of the post adsorption ultrafiltrate stream with the filtered blood stream and returning the combined post adsorption ultrafiltrate stream and the filtered blood stream to the mammal; transferring a portion of the post adsorption ultrafiltrate stream which is not returned to the mammal to a waste reservoir; and providing at least one therapeutic agent to the blood. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
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Specification