Anti-IL-6 antibodies, compositions, methods and uses
First Claim
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1. Isolated nucleic acid molecules encoding an antibody or antigen-binding fragment thereof that binds and inhibits the activity of human IL-6, wherein said antibody or antigen-binding fragment comprise:
- a human antibody heavy chain constant region and a heavy chain variable region comprising CDR1, CDR2 and CDR3, which comprise the amino acid sequences SEQ ID NO;
1, SEQ ID NO;
2 and SEQ ID NO;
3, respectively; and
a human antibody light chain constant region and a light chain variable region comprising CDR1, CDR2 and CDR3, which comprise the amino acid sequences SEQ ID NO;
4, SEQ ID NO;
5 and SEQ ID NO;
6, respectively.
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Accused Products
Abstract
The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
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Citations
9 Claims
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1. Isolated nucleic acid molecules encoding an antibody or antigen-binding fragment thereof that binds and inhibits the activity of human IL-6, wherein said antibody or antigen-binding fragment comprise:
a human antibody heavy chain constant region and a heavy chain variable region comprising CDR1, CDR2 and CDR3, which comprise the amino acid sequences SEQ ID NO;
1, SEQ ID NO;
2 and SEQ ID NO;
3, respectively; and
a human antibody light chain constant region and a light chain variable region comprising CDR1, CDR2 and CDR3, which comprise the amino acid sequences SEQ ID NO;
4, SEQ ID NO;
5 and SEQ ID NO;
6, respectively.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
Specification