Method and instrument for detecting biomolecular interactions
First Claim
1. An instrument system for detecting a biochemical interaction on a photonic crystal biosensor comprising an array of detection locations, said system comprising:
- a light source for generating collimated light;
a plurality of optical fiber probes for carrying the collimated light and directing the light to the surface of the photonic crystal biosensor and carrying the light reflected from the surface of the photonic crystal biosensor and a detection system including an imaging spectrometer receiving said reflected light and generating an image of said reflected light;
wherein the imaging spectrometer includes a one- or two-dimensional digital camera arranged as an array of pixels; and
wherein the instrument further is constructed and arranged to produce data indicating a peak wavelength value of said reflected light.
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Abstract
Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An instrument system for detecting a biochemical interaction on a biosensor. The system includes an array of detection locations comprises a light source for generating collimated white light. A beam splitter directs the collimated white light towards a surface of a sensor corresponding to the detector locations. A detection system includes an imaging spectrometer receiving the reflected light and generating an image of the reflected light.
178 Citations
6 Claims
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1. An instrument system for detecting a biochemical interaction on a photonic crystal biosensor comprising an array of detection locations, said system comprising:
- a light source for generating collimated light;
a plurality of optical fiber probes for carrying the collimated light and directing the light to the surface of the photonic crystal biosensor and carrying the light reflected from the surface of the photonic crystal biosensor and a detection system including an imaging spectrometer receiving said reflected light and generating an image of said reflected light;wherein the imaging spectrometer includes a one- or two-dimensional digital camera arranged as an array of pixels; and wherein the instrument further is constructed and arranged to produce data indicating a peak wavelength value of said reflected light. - View Dependent Claims (2, 3, 4, 5, 6)
- a light source for generating collimated light;
Specification