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Microfabricated crossflow devices and methods

  • US 7,294,503 B2
  • Filed: 09/14/2001
  • Issued: 11/13/2007
  • Est. Priority Date: 09/15/2000
  • Status: Expired due to Term
First Claim
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1. A microfluidic product comprising:

  • (a) a main channel with a diameter of between about 2 and 100 microns or cross-sectional dimensions in the range of 1 to 100 microns in fluidic communication with a source of extrusion fluid passing therethrough;

    (b) a second microfluidic channel, wherein said channel has a diameter in the range of 2 to 100 microns or cross-sectional dimensions in the range of 1 to 100 microns and is in fluidic communication with a source of sample fluid, and said sample fluid is immiscible with the extrusion fluid; and

    (c) said second microfluidic channel having at least one inlet region in communication with the main channel at a droplet extrusion region, the inlet region having a particle containing sample fluid immiscible with the extrusion fluid passing therethrough and constructed and arranged so that droplets of the sample fluid are sheared into the main channel at the extrusion region resulting in discrete sample fluid droplets containing particles in the extrusion fluid stream.

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