UK-1 analogues: methods of preparation and use
First Claim
1. A method of synthesizing a chemical compound comprising a cyclic ring having the structure II
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Abstract
The present invention includes a number of structural analogues of UK-1. A comparision of the anticancer activity of the UK-1 analogues with their ability to inhibit the growth of methicillin-sensitive and methicillin-resistant Staphylococcus aureus demonstrates that a structurally simplified analogue of UK-1 retains the natural product'"'"'s selective activity against cancer cells. Structurally conservative changes to UK-1 that diminish Mg2+-binding ability may result in a dramatic decrease in cancer cell cytotoxicity. The results may establish a minimum structural pharmacophore as well as a functional role for Mg2+-binding in the selective cytotoxicity of UK-1.
2 Citations
6 Claims
- 1. A method of synthesizing a chemical compound comprising a cyclic ring having the structure II
Specification
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- Resources
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Current AssigneeBoard of Regents of the University of Texas System (University of Texas System)
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Original AssigneeBoard of Regents of the University of Texas System (University of Texas System)
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InventorsKerwin, Sean M.
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Primary Examiner(s)McKane; Joseph K.
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Assistant Examiner(s)Coppins; Janet L.
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Application NumberUS10/720,991Publication NumberTime in Patent Office1,450 DaysField of Search548/224, 514/375, 514/613, 564/161US Class Current514/375CPC Class CodesC07D 235/18 with aryl radicals directly...C07D 263/57 Aryl or substituted aryl ra...C07D 413/04 directly linked by a ring-m...
