Microsensor system and method for measuring data

• US 7,297,113 B1
• Filed: 06/18/2004
• Issued: 11/20/2007
• Est. Priority Date: 04/25/2003
• Status: Expired due to Fees

• Current Assignee: the united states of america as represented by the secretary of the navy
• Original Assignee: the united states of america as represented by the secretary of the navy
• Inventors: Russell, Stephen D., Pugh, Jamie K., de la Houssaye, Paul R., Walker, Howard W., Pugh, William, Amundson, Dennis E.
• Primary Examiner(s): Marmor, II; Charles A.
• Assistant Examiner(s): SAIDI, AZADEH
• Application Number:
  US10/872,131
• Time in Patent Office: 1,250 Days
• Field of Search: 600/345, 600/354, 600/506, 600/302, 600/544, 600/473, 600/475, 600/322, 600/361, 600/364, 600/485, 204/153.1, 378/62, 250/458.1, 250/201.1
• US Class Current: 600/302
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

One embodiment is a microprobe. An example of the microprobe comprises a housing having an aperture. This example of the microprobe also comprises an ISFET attached to the housing. The ISFET may have a gate located proximate the aperture. This example of the microprobe further comprises a reference electrode attached to the housing proximate the aperture. Another embodiment is a microsensor system. Another embodiment is a method for measuring a characteristic of tissue. Yet another embodiment is a method for monitoring tissue pH.

Claims

1. A microsensor system, comprising:

a control module; and

at least one microprobe communicatively coupled to the control module, wherein each microprobe comprises;

a housing having an aperture;

an ISFET attached to the housing, wherein the ISFET has a gate located proximate the aperture;

reference electrode attached to the housing proximate the aperture; and

a signal bearing medium communicatively coupled to the control module, tangibly embodying a program of machine-readable instructions executable by a digital processing apparatus to perform a method for monitoring a characteristic tissue, comprising;

means for receiving medical intervention information;

means for receiving patient reference values;

means for receiving a tissue data point;

means for checking validity of said tissue data point;

means for determining a baseline mean and a baseline standard deviation for said tissue data if the baseline mean and the baseline standard deviation have not been determined for said tissue data;

means for calculating test statistics;

means for determining if a condition of said tissue data point is non-conforming;

means for flagging the condition of said tissue data point if the condition of said tissue data point is non-conforming;

means for determining if a statistically significant positive or negative trend is occurring; and

means for generating a data output signal that represents a change in patient status.

2. The microsensor system of claim 1 wherein said tissue data point is selected from the group consisting of:

pH, and blood gas.