Glucose strip sensor and glucose measurement method using the glucose strip sensor

• US 7,297,248 B2
• Filed: 10/10/2001
• Issued: 11/20/2007
• Est. Priority Date: 07/07/2001
• Status: Expired due to Term

• Current Assignee: Osang Healthcare Co., Ltd.
• Original Assignee: INFOPIA CO., LTD
• Inventors: Kwon, Mi-Joong, Bae, Byung-Woo, Kang, Byung-Soo, Lee, Seong-Dong, Park, Seong-Gi
• Primary Examiner(s): NOGUEROLA, ALEXANDER STEPHAN
• Application Number:
  US10/481,406
• Publication Number:
  US 20040146958A1
• Time in Patent Office: 2,232 Days
• Field of Search: 20440301-40303, 2044031-40312, 204/403.14, 204/409, 204/412, 204/777.5, 204/779, 204/792, 204/793.5
• US Class Current: 205/777.5
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose

Abstract

Disclosed is a disposable glucose strip sensor configured to rapidly and conveniently measure the concentration of glucose in blood and a glucose measurement method using the glucose strip sensor. In the glucose strip sensor, at least one checking electrodes are additionally provided at an electrode section including an operating electrode and a counter electrode. The checking electrode serves to check whether or not it is electrically connected with the counter electrode, upon measuring the concentration of glucose in a blood sample introduced in the sensor. Where two checking electrodes are provided, it may be checked whether or not an electrical connection is established between those checking electrodes. Based on the result of the checking, it is possible to determine whether or not a sufficient amount of blood sample is filled in the sensor. Accordingly, the measurement of glucose concentration can be accurately achieved.

Claims

1. A glucose strip sensor comprising:

a non-conductive substrate;

an electrode section formed on the substrate, the electrode section including an operating electrode and a counter electrode respectively electrically connected to lead terminals by leads;

a reaction layer formed over the electrode section and being adapted to react with a blood sample;

a resin plate adapted to define, over the electrode section, a sample receiving space for receiving the blood sample;

a cover arranged on the resin plate;

a sample introducing port arranged on a front end portion of the resin plate, the sample introducing port being adapted to introduce the blood sample into the sample receiving space by virtue of capillary phenomenon; and

discharge ports arranged on opposite sides of the glucose strip sensor and being defined by the resin plate, the discharge ports being adapted to vent air from the sample receiving space,

wherein the electrode section further comprises at least one checking electrode arranged near one of the discharge ports, the at least one checking electrode being adapted to check whether or not the blood sample is completely introduced in the sample receiving space.

2. The sensor of claim 1, wherein the at least one checking electrode is electrically connected with the counter electrode under the condition in which the sample receiving space is completely filled with the blood sample, whereby the checking electrode functions to increase a area of the counter electrode, whereby a glucose measuring signal with an increased sensitivity is obtained.

3. The sensor of claim 1, wherein the glucose strip sensor comprises a lower surface defined by the substrate, a upper surface defined by the cover, a front edge and side edges defined by the cover, the substrate, and the resin plate.

4. The sensor of claim 1, wherein the sample introducing port is arranged on a front side edge of the glucose strip sensor.

5. The sensor of claim 1, wherein the discharge ports are arranged on opposite side edges of the glucose strip sensor.

6. The sensor of claim 1, wherein the sample introducing port is arranged on a front side edge of the glucose strip sensor and is defined by the cover, the resin plate, and the substrate.

7. The sensor of claim 1, wherein the discharge ports are arranged on opposite side edges of the glucose strip sensor and is defined by the cover, the resin plate, and the substrate.

8. The sensor of claim 1, wherein the non-conductive substrate comprises a non-conductive polymer material comprising at least one of polyvinyl chloride resin and polycarbonate resin.

9. The sensor of claim 1, wherein the leads are formed by screen printing.

10. The sensor of claim 1, wherein the reaction layer comprises at least hydrogel and glucose oxidase.

11. A glucose measurement method comprising:

introducing a blood sample into the glucose strip sensor comprising a non-conductive substrate, an electrode section formed on the substrate, the electrode section including an operating electrode and a counter electrode respectively electrically connected to lead terminals by leads, a reaction layer formed over the electrode section and being adapted to react with a blood sample, a resin plate adapted to define, over the electrode section, a sample receiving space for receiving the blood sample, a cover arranged on the resin plate, a sample introducing port arranged on a front end portion of the resin plate, the sample introducing port being adapted to introduce the blood sample into the sample receiving space by virtue of capillary phenomenon, and discharge ports arranged on opposite sides of the glucose strip sensor and being defined by the resin plate, the discharge ports being adapted to vent air from the sample receiving space, wherein the electrode section further comprises at least one checking electrode arranged near one of the discharge ports, the at least one checking electrode being adapted to check whether or not the blood sample is completely introduced in the sample receiving space;

checking whether or not an electrical connection is established between the counter electrode and the checking electrode in order to determine whether or not the blood sample is introduced in the sample receiving space in a sufficient amount; and

if it is determined the blood sample is introduced in the sample receiving space in a sufficient amount, having the counter electrode also function as a counter electrode thereby increasing the counter electrode area, whereby a glucose measuring signal with an increased sensitivity is obtained; and

measuring a glucose concentration of the blood sample electrochemically.