Composition employing a novel human kinase
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Abstract
This invention provides compositions, organisms and methodologies employing a novel human protein kinase, MCRK1. The novel human kinase has sequence homology to rat myotonic dystrophy kinase-related Cdc42 binding kinase (MRCK) alpha. The gene encoding the novel kinase is localized in locus 11q13 of human chromosome 11. The novel protein kinase comprises multiple functional/structural domains that include a kinase domain, a pkinase_C domain, a DAG-PE binding domain, and a CNH domain. The sequence and structure similarity between the novel human protein and rat MRCK alpha indicates that the novel human protein may function as a downstream effector of Cdc42 in cytoskeleton reorganization.
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Citations
1 Claim
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1. An isolated polypeptide comprising SEQ ID NO:
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Specification
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Current AssigneeWyeth (Pfizer Inc.)
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Original AssigneeWyeth (Pfizer Inc.)
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InventorsLiu, Wei, Chen, Huimin, Wu, Leeying
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Primary Examiner(s)Prouty; Rebecca E.
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Application NumberUS10/702,496Publication NumberTime in Patent Office1,474 DaysField of Search435/194, 536/23.2US Class Current435/194CPC Class CodesC12N 9/1205 Phosphotransferases with an...
