Solid-phase saccharide sensing compounds
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Abstract
The present invention provides solid-phase saccharide dyes. The dyes are bisboronic acids covalently bonded to a solid substrate. The dyes selectively conjugate with saccharides, particularly glucose, and register a signal. The signal is proportional to the quantity of saccharide. Thus, the dyes of the present invention are useful for measuring and monitoring saccharide levels, particularly in biological fluids such as blood.
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Citations
28 Claims
- 1. A compound of the formula:
- 7. A compound of the formula:
- 12. A compound of the formula:
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18. A method for immobilizing a compound on a solid substrate, comprising reacting an amino-terminated hydrocarbon with a solid substrate activated with a functional group selected from the group consisting of carboxyl, carbonyl, cyanogenbromide, epoxy, and isocyanate;
wherein the amino-terminated hydrocarbon is a compound of the formula; - View Dependent Claims (19)
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22. A method for immobilizing a compound on a solid substrate, comprising reacting a carboxyl-terminated hydrocarbon with an amino-activated solid substrate, wherein the carboxyl-terminated hydrocarbon is a compound of the formula:
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23. A method for immobilizing a compound on a solid substrate comprising reacting an amino-terminated hydrocarbon with a solid substrate that is activated with a functional group selected from the group consisting of carboxyl, carbonyl, cyanogenbromide, epoxy, and isocyanate, and wherein the amino-terminated hydrocarbon is a compound of the formula:
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24. A method for immobilizing a compound on a solid substrate comprising reacting a carboxyl-terminated hydrocarbon with an amino-activated solid substrate, wherein the carboxyl-terminated hydrocarbon is a compound of the formula:
Specification