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Complexity management of genomic DNA

  • US 7,297,778 B2
  • Filed: 10/04/2002
  • Issued: 11/20/2007
  • Est. Priority Date: 07/25/2001
  • Status: Expired due to Term
First Claim
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1. A kit for genotyping at least one individual comprising an array of probes attached to a solid support, wherein the array of probes comprises:

  • at least one perfect match probe for each allele of each single nucleotide polymorphism in a collection of single nucleotide polymorphisms, said collection comprising between 10,000 and 1,500,000 single nucleotide polymorphisms, wherein a perfect match probe is exactly complementary to the polymorphic base of an allele and a region surrounding the polymorphic base;

    wherein greater than 80% of the single nucleotide polymorphisms in the collection are less than 200 kilo bases from another single nucleotide polymorphism in the collection and the average minimum distance between single nucleotide polymorphisms in the collection is between 10 and 400 kilo bases; and

    wherein each single nucleotide polymorphisms in the collection is located within a fragment that is within a selected size range when a genome is digested with a selected enzyme or enzyme combination.

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