Tissue volume reduction

• US 7,300,428 B2
• Filed: 12/11/2004
• Issued: 11/27/2007
• Est. Priority Date: 08/23/1999
• Status: Expired due to Term

• Current Assignee: Pulmonx Pulmonx
• Original Assignee: Aeris Therapeutics, Inc.
• Inventors: Ingenito, Edward P.
• Primary Examiner(s): WILLIAMS, CATHERINE SERKE
• Application Number:
  US11/009,379
• Publication Number:
  US 20050239685A1
• Time in Patent Office: 1,081 Days
• Field of Search: 604/19, 604/48, 604/500, 604/514, 604/93.01, 604/28, 604/35, 604/518, 604/522, 128/898, 514/802, 530/381, 530/382
• US Class Current: 604/500
• CPC Class Codes: A61B 1/2676 Bronchoscopes
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12104 in an air passage
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 2017/00495 for two-component glue
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 38/1825 Fibroblast growth factor [FGF]
• CPC Class Codes: A61K 38/1841 Transforming growth factor [TGF]
• CPC Class Codes: A61K 38/1858 Platelet-derived growth factor [PDGF]
• CPC Class Codes: A61K 38/363 Fibrinogen
• CPC Class Codes: A61K 38/4833 Thrombin (3.4.21.5)
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system

Abstract

Devices, compositions, and methods for achieving non-surgical lung volume reduction (e.g., bronchoscopic lung volume reduction (BLVR)) are described. BLVR can be carried out by collapsing a region of the lung, adhering one portion of the collapsed region to another, and promoting fibrosis in or around the adherent tissue.

Claims

1. A method of preparing a diseased region of a lung for volume reduction, the method comprising introducing a material into a diseased region of a lung to reduce the volume of the diseased region, wherein the material is introduced via a bronchoscope, and wherein the material comprises an anti-surfactant or an adhesive, or another biocompatible reagent, or a combination of two or more thereof;

and removing the material by suction.

2. The method of claim 1, wherein the material comprises fibrinogen.

3. The method of claim 1, wherein the material comprises 3-12% fibrinogen.

4. The method of claim 1, wherein the material comprises approximately 10% fibrinogen.

5. The method of any one of the claims 1, 2, 3, or 4, wherein the material comprises an antibiotic.