Methods and devices for retrieval of a medical agent from a physiological efferent fluid collection site

• US 7,300,429 B2
• Filed: 10/07/2004
• Issued: 11/27/2007
• Est. Priority Date: 03/18/2003
• Status: Expired due to Fees

• Current Assignee: Catharos Medical Systems, Inc.
• Original Assignee: Catharos Medical Systems, Inc.
• Inventors: Courtney, Brian K., Hassan, Ali, Fitzgerald, Peter J.
• Primary Examiner(s): Lucchesi; Nicholas D.
• Assistant Examiner(s): Koharski; Christopher
• Application Number:
  US10/962,205
• Publication Number:
  US 20050124969A1
• Time in Patent Office: 1,146 Days
• Field of Search: 604/35, 604503-508, 604/500, 604/509, 604/103.05, 604/200, 600/4, 600/514
• US Class Current: 604/508
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 2017/22082 after introduction of a substance
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/418 lymph vessels, ducts or nodes
• CPC Class Codes: A61B 5/6853 with a balloon
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61M 1/84 Drainage tubes; Aspiration tips for negative pressure wound therapy A61M1/90; for surgical cutting instruments A61B17/32
• CPC Class Codes: A61M 2025/0073 Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow
• CPC Class Codes: A61M 2025/0076 Unidirectional valves
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 25/0074 Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
• CPC Class Codes: A61M 25/0082 Catheter tip comprising a tool
• CPC Class Codes: A61M 25/1002 characterised by balloon shape A61M25/1006, A61M25/1009 take precedence

Abstract

Methods and devices for selectively removing an agent from a physiological efferent fluid collection site are provided. A feature of the invention is that a non-occlusive aspiration device is employed to selectively remove the target agent from the site only when the target agent is present in the site. Also provided are systems and kits for performing the subject methods. The subject invention finds use in a variety of different applications, including the selective removal of both therapeutic and diagnostic agents from a variety of different physiological sites.

Claims

1. A method for removing an agent from a physiological efferent fluid collection site, said method comprising:

introducing a non-occlusive aspiration element to a target aspiration site adjacent said physiological efferent fluid collection site, wherein said aspiration element does not occlude said target site when activated and comprises a detector for at least predicting the presence of said agent in said physiological efferent fluid collection site, wherein said detector is located at an upstream location of said non-occlusive aspiration element;

introducing an occlusion element to a target occlusion site proximal of the target aspiration site; and

activating said aspiration element when said agent is at least predicted to be present in said target site to selectively remove said agent from said physiological efferent fluid collection site.

2. The method according to claim 1, wherein said physiological efferent fluid collection site is a vascular fluid collection site.

3. The method according to claim 2, wherein said vascular fluid collection site is a cardiovascular fluid collection site.

4. The method according to claim 3, wherein said cardiovascular fluid collection site is a coronary cardiovascular fluid collection site.

5. The method according to claim 4, wherein said coronary cardiovascular fluid collection site is a coronary sinus.

6. The method according to claim 1, wherein said physiological efferent fluid collection site is present in a mammal.

7. The method according to claim 6, wherein said mammal is a human.

8. The method according to claim 1, wherein said agent is a therapeutic agent.

9. The method according to claim 1, wherein said agent is a diagnostic agent.

10. The method according to claim 9, wherein said diagnostic agent is a contrast agent.

11. The method according to claim 1, further comprising activating said occlusion element to prevent flow of fluid proximally of the target occlusion site.

12. The method according to claim 11, wherein said occlusion element is configured to abut a tissue structure positioned in between said target aspiration site and said target occlusion site.

13. The method according to claim 12, wherein said physiological efferent fluid collection site is a coronary sinus, said tissue structure is the coronary sinus ostium and said target occlusion site is downstream of said coronary sinus ostium.

14. The method of claim 11, wherein said occlusion element is inflatable and said activating comprises inflating said occlusion element.

15. The method of claim 11, wherein said occlusion element is expandable and said activating comprises expanding said occlusion element.

16. The method of claim 11, wherein said activating said occlusion element is accomplished passively.

17. The method according to claim 1, wherein said physiological efferent fluid collection site is present in a patient and said method results in removal of fluid from said patient.

18. The method according to claim 17, wherein said fluid is blood.

19. The method according to claim 18, wherein said method further comprises removing agent from said blood to produce filtered blood.

20. The method according to claim 19, wherein said method further comprises returning said filtered blood to said patient.

21. The method according to claim 1, wherein said detector is a fiber-optic detector.

22. The method according to claim 21, wherein said method further comprises detecting the presence of said agent in said physiological efferent fluid collection site using said detector.

23. The method according to claim 1, wherein said detector is located at the vicinity of said target site.