SC6 for diagnosis of cancers

• US 7,300,765 B2
• Filed: 04/02/2003
• Issued: 11/27/2007
• Est. Priority Date: 04/02/2002
• Status: Expired due to Fees

• Current Assignee: UCB Pharma SA (UCB SA)
• Original Assignee: UCB Pharma SA (UCB SA)
• Inventors: Patel, Sonal
• Primary Examiner(s): Saoud; Christine J.
• Assistant Examiner(s): LOCKARD, JON MCCLELLAND
• Application Number:
  US10/509,975
• Publication Number:
  US 20050181368A1
• Time in Patent Office: 1,700 Days
• Field of Search: None
• US Class Current: 435/7.23
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: C07K 14/47 from mammals
• CPC Class Codes: G01N 2800/52 Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
• CPC Class Codes: G01N 33/574 for cancer
• CPC Class Codes: G01N 33/68 involving proteins, peptides or amino acids involving lipoproteins G01N33/92

Abstract

The present invention relates to new uses of Solute Carrier 6 (SC6), a taurine transporter, in the diagnosis, screening, treatment and prophylaxis of hypoxia related conditions e.g. cancer. Compositions comprising the protein, such as vaccines and agents that modulate the protein expression or activity, including antibodies that are immunospecific for the protein, are also provided.

Claims

1. A method of diagnosing cervical, breast, colon, renal, lung or uterine cancer in a subject or monitoring the effectiveness of therapy for said condition, which comprises

a) detecting and/or quantifying in a biological sample obtained from said subject an SC6 polypeptide comprising the amino acid sequence of SEQ ID NO:

1; and

b) comparing the level of SC6 polypeptide in a biological sample obtained from the subject with the level of SC6 polypeptide in a normal sample wherein a diagnosis of cervical, breast, colon, renal, lung or uterine cancer is made if an elevated level of said SC6 polypeptide occurs in the subject relative to the level of said SC6 polypeptide in the normal sample.

2. The method according to claim 1 wherein the polypeptide is detected and/or quantified using an antibody that specifically binds to an SC6 polypeptide.