Analyte detection system
First Claim
1. A particle comprising:
- two or more than two fluorescent labels embedded within the particle in a combination of relative amounts, the fluorescent labels being capable of being excited by light of a same excitation wavelength and capable of emitting lights at maximum wavelengths greater than about 750 nm, distinguishable from each other, respectively.
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Accused Products
Abstract
An analyte detection system utilizing a combination of fluorescent labels for labeling particles and an analyte specific fluorescent analyte detection dye. The particles contain a combination of fluorescent labels for coding the particles and an analyte specific fluorescent dye. The particles can be used to identify and quantify analytes in an analytical sample by reaction of the analytical sample with the particles. An analytical device can identify the particles according to the combination of fluorescent labels. The device can then correlate the identified particle with the analyte specific fluorescent analyte detection dye. Multiple subpopulations of particles can be used to identify and quantify multi-analytes in a single analytical sample. Near infrared (NIR) fluorescent labels useful in the detection system are also provided.
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Citations
21 Claims
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1. A particle comprising:
two or more than two fluorescent labels embedded within the particle in a combination of relative amounts, the fluorescent labels being capable of being excited by light of a same excitation wavelength and capable of emitting lights at maximum wavelengths greater than about 750 nm, distinguishable from each other, respectively. - View Dependent Claims (2, 3, 4, 5, 6, 7, 14, 15, 16, 17, 18, 19, 20, 21)
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8. An analyte detection system comprising:
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a) one or more than one particle, each particle comprising two or more than two fluorescent labels in a combination of relative amounts, wherein each fluorescent label is capable of being excited by light of a same excitation wavelength and capable of emitting light when excited at maximum wavelengths greater than about 750 nm, distinguishable from each other, respectively; b) means for exciting the fluorescent labels; c) means for detecting the emitted lights; and d) means for correlating the detected emitted lights with a particular particle under analysis. - View Dependent Claims (9, 10, 11)
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12. An assay system comprising:
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a) a particle having (i) two or more than two fluorescent labels, each fluorescent label being capable of being excited by light of a same second excitation wavelength and capable of emitting light when excited at maximum wavelengths greater than about 750 nm, distinguishable from each other, respectivley; and (ii) a receptor; b) an analyte; and c) a fluorescent analyte detection dye, wherein the fluorescent analyte detection dye has an emitting light that differs from the wavelengths of emitted lights of each of the fluorescent labels by at least 100 nm. - View Dependent Claims (13)
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Specification