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Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor

  • US 7,300,803 B2
  • Filed: 08/22/2006
  • Issued: 11/27/2007
  • Est. Priority Date: 10/30/2000
  • Status: Expired due to Term
First Claim
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1. A method of detecting cleavage of one or more entire specific binding substances from a surface of a colorimetric resonant reflectance optical biosensor, wherein one or more specific binding substances are immobilized on the surface of the biosensor at distinct locations, comprising:

  • a. detecting a colorimetric resonant reflectance optical biosensor peak wavelength value (PWV) of the distinct locations;

    b. applying one or more cleaving molecules to the distinct locations;

    c. detecting a colorimetric resonant reflectance optical PWV of the distinct locations; and

    d. comparing the PWVs from step (a) with the PWVs from step (c);

    wherein the cleavage of one or more entire specific binding substances is detected.

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