Enhanced optical coherence tomography for anatomical mapping

• US 7,301,644 B2
• Filed: 09/06/2005
• Issued: 11/27/2007
• Est. Priority Date: 12/02/2004
• Status: Active Grant

• Current Assignee: University of Miami
• Original Assignee: University of Miami
• Inventors: Puliafito, Carmen A., Gregori, Giovanni, Knighton, Robert W., Jiao, Shuliang
• Primary Examiner(s): Lyons; Michael A.
• Application Number:
  US11/219,992
• Publication Number:
  US 20060119858A1
• Time in Patent Office: 812 Days
• Field of Search: 356/451, 356/456, 356/477, 356/479, 356/497, 250/227.19, 250/227.27
• US Class Current: 356/479
• CPC Class Codes: A61B 3/102 for optical coherence tomography [OCT]
• CPC Class Codes: G01B 9/02044 Imaging in the frequency domain, e.g. by using a spectrometer
• CPC Class Codes: G01B 9/02089 Displaying the signal, e.g. for user interaction
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence

Abstract

A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.

Claims

1. An apparatus for obtaining images of an object comprising:

a spectral domain optical coherence tomography (OCT) system, said system including a light source, a beam splitter for dividing the light along a sample path and a reference path, said sample path further including a scanner for scanning the light in at least one of the X and Y directions over the sample;

a detector for receiving light returned from both the sample and the reference paths and generating a plurality of sets of outputs, each set corresponding to varying intensities at different wavelengths of said source at a particular X/Y position of said light on said sample, said intensities including information about the reflection distribution along the sample in the Z axis; and

a processor for directly converting each set of outputs into a single intensity value corresponding to the integrated intensity in the Z axis for the associated X/Y position of the light on the sample, said single intensity values being suitable for generating a two dimensional image intensity map of the object.

2. An apparatus as recited in claim 1, further including a monitor for displaying the intensity values as a two dimensional intensity map.

3. An apparatus as recited in claim 1, wherein said processor converts the detector outputs to intensity values by one of (a) summing the outputs, (b) squaring and then summing the outputs, or (c) high pass filtering or high pass filtering and then squaring and summing the results.

4. An apparatus as recited in claim 1, wherein the two dimensional intensity map is used to register an image obtained with another imaging modality.

5. An apparatus as recited in claim 1, wherein the processor further converts the detector outputs into a 3-D data set with Z-axis intensity information for each X/Y position, said 3-D data set being suitable for generating OCT cross-sectional images.

6. An apparatus as recited in claim 5, wherein the two dimensional intensity map is used to register an OCT cross-sectional image.

7. An apparatus as recited in claim 5, wherein the intensity map is displayed in parallel with an OCT cross-sectional image.

8. An apparatus as recited in claim 5, wherein the processor further functions to segment the 3-D data set based on landmarks.

9. An apparatus as recited in claim 8, wherein the landmarks are identified from the information generated from the intensity map.

10. An apparatus as recited in claim 8, wherein the landmarks include a pair of physical boundaries within the sample.

11. An apparatus as recited in claim 8, wherein the segmented data is used to generate a partial intensity image.

12. An apparatus as recited in claim 8, wherein the segmented data is used to generate an ocular map.

13. An apparatus as recited in claim 8, wherein the segmented data is used to quantify fluid filled spaces.

14. An apparatus as recited in claim 1, wherein the light source is a broadband light source and the detector is a spectrometer.

15. An apparatus as recited in claim 14, wherein the spectrometer includes a grating and a detector array.

16. An apparatus as recited in claim 1, wherein the light source is tunable and swept and intensity at different wavelengths is obtained over time.

17. An apparatus for obtaining images of an object comprising:

a spectral domain optical coherence tomography (SD-OCT) system, said system including a scanner for scanning a light beam in at least one of the X and Y directions over the sample, said system being one of a swept source SD-OCT system and a spectrometer based SD-OCT system, said system generating a plurality of sets of outputs, each set corresponding to varying intensities at different wavelengths of said source at a particular X/Y position of said light on said sample, said intensities including information about the reflection distribution along the sample in the Z axis; and

a processor for directly converting each set of outputs into a single intensity value corresponding to the integrated intensity in the Z axis for the associated X/Y position of the light on the sample, said single intensity values being suitable for generating a two dimensional image intensity map of the object.

18. An apparatus as recited in claim 17, further including a monitor for displaying the intensity values as a two dimensional intensity map.

19. An apparatus as recited in claim 17, wherein said processor converts the outputs to intensity values by one of (a) summing the outputs, (b) squaring and then summing the outputs, or (c) high pass filtering or high pass filtering and then squaring and summing the results.

20. An apparatus as recited in claim 17, wherein the SD-OCT system is spectrometer based and the light source is a broadband light source.

21. A method of generating intensity images of an object utilizing outputs generated by a spectral domain optical coherence tomography (SD-OCT) system, said system including a scanner for scanning a light beam in at least one of the X and Y directions over the sample, said system being one of a swept source SD-OCT system and a spectrometer based SD-OCT system, said system generating a plurality of sets of outputs, each set corresponding to varying intensities at different wavelengths of said source at a particular X/Y position of said light on said sample, said intensities including information about the reflection distribution along the sample in the Z axis, said method comprising the steps of:

directly converting each set of outputs into a single intensity value corresponding to the integrated intensity in the Z axis for the associated X/Y position of the light on the sample; and

generating a two-dimensional intensity map of the integrated intensity values.

22. A method as recited in claim 21, further including the step of displaying the intensity map on a monitor.

23. A method as recited in claim 21, wherein the step of converting outputs into single intensity values is performed by one of (a) summing the outputs, (b) squaring and then summing the outputs, or (c) high pass filtering or high pass filtering and then squaring and summing the results.

24. A method as recited in claim 21, further including the step of using the two dimensional intensity map to register an image obtained with another imaging modality.

25. A method as recited in claim 21, further including the step of converting the outputs into a 3-D data set with Z-axis intensity information for each X/Y position, said 3-D data set being suitable for generating OCT cross-sectional images.

26. A method as recited in claim 25, further including the step of using the two dimensional intensity map to register an OCT cross-sectional image.

27. A method as recited in claim 25, further including the step of displaying the intensity map in parallel with an OCT cross-sectional image.

28. A method as recited in claim 25, further including the step of segmenting the 3-D data set based on landmarks.

29. A method as recited in claim 28, wherein the landmarks are identified from the information generated from the intensity map.

30. A method as recited in claim 28, wherein the landmarks include a pair of physical boundaries within the sample.

31. A method as recited in claim 28, wherein the segmented data is used to generate a partial intensity image.

32. A method as recited in claim 28, wherein the segmented data is used to generate an ocular map.

33. A method as recited in claim 28, wherein the segmented data is used to quantify fluid filled spaces.

34. An apparatus for obtaining images of an object comprising:

a spectral domain optical coherence tomography (OCT) system, said system including a light source, a beam splitter for dividing the light along a sample path and a reference path, said sample path further including a scanner for scanning the light in at least one of the X and Y directions over the sample;

a detector for receiving light returned from both the sample and the reference paths and generating a plurality of sets of outputs, each set corresponding to varying intensities at different wavelengths of said source at a particular X/Y position of said light on said sample, said intensities including information about the reflection distribution along the sample in the Z axis; and

a processor for converting the outputs of each set of outputs into a 3-D data set including Z-axis intensity information for each X/Y position, said 3-D data sets being suitable for generating OCT cross-sectional images, said processor further for converting at least some of the 3-D data set into a single intensity value corresponding to the integrated intensity across at least a portion of the Z axis for the associated X/Y position of the light on the sample, said single intensity values being suitable for generating a two dimensional image intensity map of the object.

35. An apparatus as recited in claim 34, further including a monitor for displaying the intensity values as a two dimensional intensity map.

36. An apparatus as recited in claim 34, wherein the two dimensional intensity map is used to register an OCT cross-sectional image.

37. An apparatus as recited in claim 34, wherein the intensity map is displayed in parallel with an OCT cross-sectional image.

38. An apparatus as recited in claim 34, wherein the two dimensional intensity map is used to register an image obtained with another imaging modality.

39. An apparatus as recited in claim 34, wherein the processor further functions to segment the 3-D data set based on landmarks.

40. An apparatus as recited in claim 39, wherein the landmarks are identified from the information generated from the intensity map.

41. An apparatus as recited in claim 39, wherein the landmarks include a pair of physical boundaries within the sample.

42. An apparatus as recited in claim 39, wherein the segmented data is used to generate a partial intensity image.

43. An apparatus as recited in claim 34, wherein the light source is a broadband light source and the detector is a spectrometer.

44. An apparatus for obtaining images of an object comprising:

a spectral domain optical coherence tomography (SD-OCT) system, said system including a scanner for scanning a light beam in at least one of the X and Y directions over the sample, said system being one of a swept source SD-OCT system and a spectrometer based SD-OCT system, said system generating a plurality of sets of outputs, each set corresponding to varying intensities at different wavelengths of said source at a particular X/Y position of said light on said sample, said intensities including information about the reflection distribution along the sample in the Z axis; and

a processor for converting the outputs of each set of outputs into a 3-D data set including Z-axis intensity information for each X/Y position, said 3-D data sets being suitable for generating OCT cross-sectional images, said processor further for converting at least some of the 3-D data set into a single intensity value corresponding to the integrated intensity across at least a portion of the Z axis for the associated X/Y position of the light on the sample, said single intensity values being suitable for generating a two dimensional image intensity map of the object.

45. An apparatus as recited in claim 44, further including a monitor for displaying the intensity values as a two dimensional intensity map.

46. An apparatus as recited in claim 44, wherein the two dimensional intensity map is used to register an OCT cross-sectional image.

47. An apparatus as recited in claim 44, wherein the intensity map is displayed in parallel with an OCT cross-sectional image.

48. An apparatus as recited in claim 44, wherein the two dimensional intensity map is used to register an image obtained with another imaging modality.

49. An apparatus as recited in claim 44, wherein the processor further functions to segment the 3-D data set based on landmarks.

50. An apparatus as recited in claim 49, wherein the landmarks are identified from the information generated from the intensity map.

51. An apparatus as recited in claim 49, wherein the landmarks include a pair of physical boundaries within the sample.

52. An apparatus as recited in claim 49, wherein the segmented data is used to generate a partial intensity image.

53. An apparatus as recited in claim 44, wherein the SD-OCT system is spectrometer based and the light source is a broadband light source.

54. A method of generating intensity images of an object utilizing the output from a spectral domain optical coherence tomography (SD-OCT) system, said system including a scanner for scanning a light beam in at least one of the X and Y directions over the sample, said system being one of a swept source SD-OCT system and a spectrometer based SD-OCT system, said system generating a plurality of sets of outputs, each set corresponding to varying intensities at different wavelengths of said source at a particular X/Y position of said light on said sample, said intensities including information about the reflection distribution along the sample in the Z axis, said method comprising the steps of:

converting the outputs of each set of outputs into a 3-D data set including Z-axis intensity information for each X/Y position, said 3-D data set being suitable for generating OCT cross-sectional images;

converting at least some of the 3-D data set into a single intensity value corresponding to the integrated intensity across at least a portion of the Z axis for the associated X/Y position of the light on the sample; and

generating a two dimensional image map of the integrated intensity values.

55. A method as recited in claim 54, further including the step of displaying the intensity map on a monitor.

56. A method as recited in claim 54, further including the step of using the two dimensional intensity map to register an OCT cross-sectional image.

57. A method as recited in claim 54, further including the step of displaying the intensity map in parallel with an OCT cross-sectional image.

58. A method as recited in claim 54, further including the step of using the two dimensional intensity map to register an image obtained with another imaging modality.

59. A method as recited in claim 54, further including the step of segmenting the 3-D data set based on landmarks.

60. A method as recited in claim 59, wherein the landmarks are identified from the information generated from the intensity map.

61. A method as recited in claim 59, wherein the landmarks include a pair of physical boundaries within the sample.

62. A method as recited in claim 59, wherein the segmented data is used to generate a partial intensity image.

63. An apparatus for obtaining images of an object comprising:

a spectral domain optical coherence tomography (OCT) system, said system including a broad band light source, a beam splitter for dividing the light along a sample path and a reference path, said sample path further including a scanner for scanning the light in at least one of the X and Y directions onto the sample;

a detector for receiving light returned from both the sample and the reference paths, said detector including a spectrometer and a line scan camera for generating a plurality of sets of outputs, each set corresponding to varying intensities at different wavelengths of said source at a particular X/Y position of said light on said sample, said intensities including information about the reflection distribution along the sample in the Z axis, said detector further including an auxiliary detector element for monitoring zero order light and generating an output corresponding to the integrated intensity in the Z axis for the associated X/Y position of the light on the sample; and

a processor for converting each set of outputs from the line scan camera into a 3-D data set including Z-axis intensity information for each X/Y position, said 3-D data set being suitable for generating cross-sectional images, said processor for converting the outputs from the auxiliary detector element into a format suitable for generating a two dimensional image intensity map of the object.