Choline transport like (CTL) membrane proteins involved in choline transport
First Claim
1. A purified or isolated nucleic acid comprising a nucleic acid sequence selected from the group consisting of:
- a) the sequence SEQ ID NO;
1;
b) the complementary sequence of SEQ ID NO;
1; and
c) the RNA sequence corresponding to SEQ ID NO;
1.
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Accused Products
Abstract
The invention concerns the identification of a novel family of CTL (Choline Transporter Like) genes, in particular hCTL1 and hCTL2, involved in the metabolism and/or transport of choline in cells such as the intestinal tract cells, nervous cells, in particular motoneurons, sensitive neurons, neurons of the nucleus dorsalis of the spinal cord and oligodendrocytes. The invention opens up new prospects in particular for the treatment of familial dysautonomia, and Tangier disease. More generally, the identification of CTL genes enables to develop new strategies for treating diseases of the nervous system, in particular neurodegenerative demyelenating diseases, particularly Alzheimer disease, Parkinson disease and Huntington disease.
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Citations
8 Claims
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1. A purified or isolated nucleic acid comprising a nucleic acid sequence selected from the group consisting of:
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a) the sequence SEQ ID NO;
1;b) the complementary sequence of SEQ ID NO;
1; andc) the RNA sequence corresponding to SEQ ID NO;
1.
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2. An isolated nucleic acid encoding a polypeptide selected from the group consisting of:
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SEQ ID NO;
3; andSEQ ID NO;
9.
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3. A vector comprising a nucleic acid sequence selected from the group consisting of:
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a) the sequence SEQ ID NO;
1; andb) the complementary sequence or the RNA sequence corresponding to SEQ ID NO;
1. - View Dependent Claims (5, 6)
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4. A vector comprising a nucleic acid sequence encoding a polypeptide selected from the group consisting of:
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SEQ ID NO;
3; andSEQ ID NO;
9.
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7. A method for the amplification and/or detection of a target nucleic acid in a sample, said target nucleic acid having a sequence selected from the group consisting of:
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a) the sequence SEQ ID NO;
1;b) the complementary sequence or the RNA sequence corresponding to a sequence as defined in a); and c) a sequence capable of hybridizing to a sequence as defined in a) or b), the method comprising; hybridizing the sample with a primer and/or probe comprising at least 12 contiguous nucleotides comprising a sequence complementary to said target polynucleotide in the sample, and which probe specifically hybridizes to said target polynucleotide, under conditions whereby a hybridization complex is formed between said probe and said target nucleic acid.
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8. A method for the amplification and/or detection of a target nucleic acid in a sample, said target nucleic acid encoding a polypeptide selected from the group consisting of:
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a) SEQ ID NO;
3; andb) SEQ ID NO;
9;or a sequence capable of hybridizing to a nucleic acid sequence encoding a) or b) the method comprising; hybridizing the sample with a primer and/or probe comprising at least 12 contiguous nucleotides comprising a sequence complementary to said target polynucleotide in the sample, and which probe specifically hybridizes to said target polynucleotide, under conditions whereby a hybridization complex is formed between said probe and said target nucleic acid.
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Specification