Nucleic acid encoding novel type-1 cytokine receptor GLM-R
First Claim
1. An isolated nucleic acid molecule which comprises (a) a nucleic acid encoding a GLM-R polypeptide that (i) is expressed in activated monocytes and preferentially phosphorylates STAT3 and (ii) has at least 95% sequence identity to the sequence of amino acid residues from 1 or 20 to 732 of FIG. 2 (SEQ ID NO:
- 2), or (b) the complement of the nucleic acid molecule of (a).
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Abstract
The present invention is directed to novel polypeptides and variants thereof of GLM-R polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided are methods for detecting agents that modulate the activity of GLM-R. Also provided are methods for diagnosing and for treating disorders characterized by the over or under abundance of monocytes or macrophages.
40 Citations
15 Claims
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1. An isolated nucleic acid molecule which comprises (a) a nucleic acid encoding a GLM-R polypeptide that (i) is expressed in activated monocytes and preferentially phosphorylates STAT3 and (ii) has at least 95% sequence identity to the sequence of amino acid residues from 1 or 20 to 732 of
FIG. 2 (SEQ ID NO:- 2), or (b) the complement of the nucleic acid molecule of (a).
- View Dependent Claims (2, 3, 4, 9, 10, 11, 12, 13, 14, 15)
- 5. An isolated nucleic acid molecule which comprises (a) a nucleic acid encoding a GLM-R polypeptide that (i) is expressed in activated monocytes and preferentially phosphorylates STAT3 and (ii) has at least 95% sequence identity to (a) the polypeptide encoded by the human protein cDNA deposited with the ATCC on May 16, 2000 under ATCC Deposit No. 1874-PTA (DNA173920-2924), or (b) the complement of the nucleic acid molecule of (a).
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7. An isolated nucleic acid molecule which comprises (a) a nucleic acid encoding a GLM-R polypeptide that (i) is expressed in activated monocytes and preferentially phosphorylates STAT3 and (ii) has at least 95% sequence identity to the sequence of amino acid residues from X to 732 of
FIG. 2 (SEQ ID NO:- 2) or (b) the complement of the nucleic acid molecule of (a), wherein X is any amino acid residue from 15 to 24 of
FIG. 2 (SEQ ID NO;
2).
- 2) or (b) the complement of the nucleic acid molecule of (a), wherein X is any amino acid residue from 15 to 24 of
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8. A nucleic acid molecule deposited with the ATCC under accession number 1874-PTA (DNA173920-2924).
Specification