Matrix protein composition for dentin regeneration
First Claim
1. A method of promoting one or more of regeneration of secondary dentin, formation of reparative dentin, or formation of osteodentin in a mammal, the method comprising administering to exposed vital dental pulp tissue of said mammal an active enamel substance comprising enamel matrix proteins selected from the group including one or more of enamelins, amelogenins, amelins, ameloblastin, sheathlin, tuftelins, dentinsialoprotein, and dentinsialophosphoprotein in an amount sufficient to promote one or more of regeneration of secondary dentin or formation of reparative dentin or formation of osteodentin.
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Abstract
The present invention relates to the surprising finding that enamel matrix, enamel matrix derivatives and/or enamel matrix proteins induce dentin regeneration. The invention thus relates to the use of a preparation of an active enamel substance for the preparation of a pharmaceutical composition for the formation or regeneration of dentin following dental procedures involving exposure of vital dental pulp tissue. In another aspect, the invention relates to a method of promoting the formation or regeneration of dentin following dental procedures involving exposure of vital dental pulp tissue, the method comprising applying an effective amount of an active enamel substance on exposed vital dental pulp tissue after dental procedures.
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Citations
37 Claims
- 1. A method of promoting one or more of regeneration of secondary dentin, formation of reparative dentin, or formation of osteodentin in a mammal, the method comprising administering to exposed vital dental pulp tissue of said mammal an active enamel substance comprising enamel matrix proteins selected from the group including one or more of enamelins, amelogenins, amelins, ameloblastin, sheathlin, tuftelins, dentinsialoprotein, and dentinsialophosphoprotein in an amount sufficient to promote one or more of regeneration of secondary dentin or formation of reparative dentin or formation of osteodentin.
Specification