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Engineered particles and methods of use

  • US 7,306,787 B2
  • Filed: 03/12/2002
  • Issued: 12/11/2007
  • Est. Priority Date: 09/29/1997
  • Status: Expired due to Fees
First Claim
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1. A method of delivering a therapeutic dose of a bioactive agent to the pulmonary air passages in a single breath, the method comprising:

  • providing a receptacle containing a mass of particles, the particles comprising a bioactive agent and having perforated microstructures with a bulk density of less than 0.5 g/cm3; and

    administering the particles as an aerosol from the receptacle to a subject'"'"'s respiratory tract;

    wherein the particles are sized and shaped so that at least 50% of the mass of the particles are delivered to the subject'"'"'s respiratory tract and wherein the fine particle fraction of particles of the aerosol is greater than 60% w/w.

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