Optical-based sensing devices

• US 7,308,292 B2
• Filed: 04/15/2005
• Issued: 12/11/2007
• Est. Priority Date: 04/15/2005
• Status: Expired due to Fees

• Current Assignee: Sensors For Medicine and Science Incorporated
• Original Assignee: Sensors For Medicine and Science Incorporated
• Inventors: O'Connor, Casey J., DeHennis, Andrew D., Colvin, Arthur E.
• Primary Examiner(s): Mantis-Mercader; Eleni
• Assistant Examiner(s): Berhanu; Etsub D
• Application Number:
  US11/106,481
• Publication Number:
  US 20060231749A1
• Time in Patent Office: 970 Days
• Field of Search: 600/309, 600/310, 600/316, 600/317, 600/322, 600/341
• US Class Current: 600/310
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/07 Endoradiosondes
• CPC Class Codes: A61B 5/6861 Capsules, e.g. for swallowing or implanting
• CPC Class Codes: G01N 2021/7786 Fluorescence
• CPC Class Codes: G01N 21/645 Specially adapted constructive features of fluorimeters
• CPC Class Codes: G01N 21/77 by observing the effect on a chemical indicator

Abstract

The present invention provides an electro-optical sensing device for detecting the presence or concentration of an analyte. More particularly, the invention relates to (but is not in all cases necessarily limited to) optical-based sensing devices which are characterized by being totally self-contained, with a smooth and rounded oblong, oval, or elliptical shape (e.g., a bean- or pharmaceutical capsule-shape) and a size which permits the device to be implanted in humans for in-situ detection of various analytes.

Claims

1. An electro-optical sensing device for detecting the presence or concentration of an analyte, comprising:

a housing having an outer surface;

a plurality of indicator molecules located on at least a portion of the outer surface of the housing;

a circuit board housed within the housing;

a support member having a side that lies on a plane that is substantially perpendicular to a plane on which a top side of the circuit board lies;

a radiation source attached to said side of the support member and positioned a distance above the top side of the circuit board; and

a photodetector attached to the circuit board for detecting a response of the indicator molecules.

2. The sensing device of claim 1, wherein said circuit board has a groove in the top side thereof and said support member has an end inserted into said groove.

3. The sensing device of claim 1, wherein the distance ranges between about 0.010 inches and 0.030 inches.

4. The sensing device of claim 1, further comprising a reflector spaced apart from the radiation source and having a reflective side that faces the radiation source.

5. The sensing device of claim 4, wherein the photodetector is positioned in a location beneath a region between the radiation source and the reflective side of the reflector.

6. The sensing device of claim 5, wherein the photodetector has a photosensitive side that faces in a direction substantially perpendicular to the direction that the reflective side of the reflector faces.

7. The sensing device of claim 6, wherein the photosensitive side of the photodetector is positioned below the top side of the circuit board.

8. The sensing device of claim 7, wherein the circuit board has a hole that extends from the top side to a bottom side.

9. The sensing device of claim 8, wherein the photodetector is attached to the bottom side of the circuit board.

10. The sensing device of claim 4, wherein said circuit board has a groove in the top side thereof and said reflector has an end inserted into said groove.

11. The sensing device of claim 1, wherein a first electrical contact is disposed on a surface of the support member and the radiation source is electrically connected to the electrical contact.

12. The sensing device of claim 11, wherein the first electrical contact is electrically connected to a second electrical contact disposed on the circuit board.

13. The sensing device of claim 12, further comprising a circuit trace disposed on or within the support member that functions to electrically connect the first electrical contact with the second electrical contact.

14. An electro-optical sensing device for detecting the presence or concentration of an analyte, comprising:

a housing having an outer surface;

a plurality of indicator molecules located on at least a portion of the outer surface of the housing;

a circuit board housed within the housing;

a photodetector having a top side and a bottom side, wherein the photodetector is electrically connected to a circuit on the circuit board and at least a top side of the photodetector is photosensitive;

a filter having a top side and a bottom side, the bottom side being positioned over the top side of the photodetector; and

a radiation source positioned over the top side of the filter.

15. The sensor of claim 14, further comprising a base having a top side and a bottom side, the bottom side being attached to an end of the circuit board, wherein the bottom side of the photodetector is mounted on the top side of the base.

16. The sensor of claim 15, wherein the top side of the base lies in a plane that is substantially perpendicular to a plane on which a top side of the circuit board lies.

17. The sensor of claim 16, wherein the top side of the photodetector is generally parallel with the top side of the base.

18. The sensor of claim 15, wherein the bottom side of the base has a groove therein, and the end of the circuit board is inserted into the groove.

19. The sensor of claim 15, further comprising:

a first electrical contact disposed on the base; and

a second electrical contact disposed on the base, wherein

the photodetector is electrically connected to the first electrical contact, and

the radiation source is electrically connected to the second electrical contact.

20. The sensor of claim 19, wherein the first electrical contact is electrically connected to a third electrical contact disposed on the circuit board and the second electrical contact is electrically connected to a fourth electrical contact disposed on the circuit board.

21. The sensor of claim 20, further comprising a circuit trace disposed on or within the base that functions to electrically connect the first electrical contact with the third electrical contact and the second electrical contact with the fourth electrical contact.

22. The sensor of claim 14, wherein the top side of the photodetector lies in a plane that is substantially parallel with a plane on which a top side of the circuit board lies.

23. The sensor of claim 14, further comprising an opaque base disposed between the radiation source and the filter.

24. The sensor of claim 23, wherein the base comprises molybdenum.

25. The sensor of claim 14, wherein the filter is fixed to the photodetector using an epoxy.

26. The sensor of claim 25, wherein the epoxy is disposed between the bottom side of the filter and the top side of the photodetector.

27. The sensor of claim 26, wherein the reflective index of the epoxy matches the reflective index of the filter.

28. The sensor of claim 14, wherein the radiation source is light emitting diode.