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Modeling and evaluation metabolic reaction pathways and culturing cells

  • US 7,308,363 B2
  • Filed: 01/23/2002
  • Issued: 12/11/2007
  • Est. Priority Date: 01/23/2002
  • Status: Expired due to Fees
First Claim
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1. A method for evaluating at least one metabolic pathway and culturing cells, the method comprising:

  • generating a symbolic model that represents a network comprising chemical reactions of the at least one metabolic pathway;

    evaluating the symbolic model to identify a first set of precursor substrates and/or chemical reactions that are sufficient to produce a set of target products or a second set of precursor substrates and/or chemical reactions that are insufficient to produce the set of target products, wherein the symbolic model comprises a Boolean function that returns a predetermined value if the set of target compounds is produced; and

    culturing cells in a medium selected based upon identification of one of the first and second sets to selectively support viability of the cells.

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