Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients

• US 7,309,497 B2
• Filed: 08/21/2001
• Issued: 12/18/2007
• Est. Priority Date: 08/24/2000
• Status: Expired due to Fees

• Current Assignee: UCB Pharma GmbH (UCB SA)
• Original Assignee: Schwarz Pharma Ag (Schwarz Pharma)
• Inventors: Rimpler, Stephan, Grapatin, Sabine, Krein, Cliff, Thelen, Markus
• Primary Examiner(s): Sheikh, Humera N.
• Application Number:
  US10/344,863
• Publication Number:
  US 20030180332A1
• Time in Patent Office: 2,310 Days
• Field of Search: 424/422, 424/400
• US Class Current: 424/422
• CPC Class Codes: A61K 31/381 having five-membered rings
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Abstract

The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient in a solid phase, (b) a vehicle consisting substantially of polyol fatty acid esters with a degree of esterification of over 80%, and (c) a wetting agent consisting substantially of polyol fatty acid esters with a monoester proportion of over 60%. The inventive composition is used for the systemic administration of numerous pharmacologically active ingredients, whereby the ingredients are released from the pharmaceutical composition over a period of at least 12, preferably at least 24 hours.

Claims

1. An injectable pharmaceutical composition comprising:

(a) at least one pharmacologically active agent in its solid phase;

(b) a vehicle essentially consisting of polyol fatty acid esters with an esterification level of over 80%; and

(c) a wetting agent comprising polyol fatty acid esters with a monoester content of over 60%,

wherein the active agent is an antiparkinsonian agent which is released in the body from the injectable pharmaceutical composition in a therapeutically effective amount over a time period of at least 24 hours.

2. The injectable pharmaceutical composition of claim 1, wherein the vehicle is more than 70% (w/w) of the total composition.

3. The pharmaceutical composition of claim 1 or 2 wherein the pharmaceutical composition is anhydrous.

4. The pharmaceutical composition of claim 1 or 2 wherein the pharmacologically active agent is substantially insoluble in the pharmaceutical composition.

5. The pharmaceutical composition of claim 1 or 2 wherein the vehicle consists essentially of polyol fatty acid esters containing as the polyol component 1,3-propanediol, 1,3-butanediol or glycerol.

6. The pharmaceutical composition of claim 1 or 2 wherein the vehicle consists essentially of polyol fatty acid esters containing over 90% saturated fatty acids.

7. The pharmaceutical composition of claim 1 or 2 wherein the vehicle consists essentially of polyol fatty acid esters containing fatty acids with a chain length of 6 to 14 C-atoms.

8. The pharmaceutical composition of claim 1 or 2 wherein the vehicle consists essentially of medium-chain triglycerides.

9. The pharmaceutical composition of claim 1 or 2 wherein the wetting agent consists essentially of polyol fatty acid esters containing as the polyol component 1,3-propanediol, glycerol, 1,2,3-butanetriol, 1,2,4-butanetriol, 1,3-butanediol, sorbitan or isopropanol.

10. The pharmaceutical composition of claim 1 or 2 wherein the wetting agent consists essentially of polyol fatty acid esters containing over 90% saturated fatty acids.

11. The pharmaceutical composition of claim 1 or 2 wherein the wetting agent consists essentially of polyol fatty acid esters containing fatty acids with a chain length of 6 to 14 C-atoms.

12. The pharmaceutical composition of claim 1 or 2 wherein the wetting agent consists essentially of glycerol monolaurate or glycerol monocaprylate.

13. The pharmaceutical composition of claim 1 or 2 wherein the wetting agent is present at a concentration of 0.1–

5% (w/w).

14. The pharmaceutical composition of claim 1 or 2 wherein the pharmaceutical composition is free of any phosphatides.

15. The pharmaceutical composition of claim 1 or 2 wherein the pharmacologically active agent is present in crystalline form.

16. The pharmaceutical composition of claim 1 or 2 wherein the pharmacologically active agent is present in an amorphous form.

17. The pharmaceutical composition of claim 1 or 2 wherein the pharmacologically active agent is present in salt form.

18. The pharmaceutical composition of claim 1 wherein the active agent is present at a concentration of from 0.01 to 20% (w/v).

19. The pharmaceutical composition of claim 1 wherein the active agent is present at a concentration of from 0.02 to 5% (w/v).

20. The pharmaceutical composition of claim 3 wherein the active agent is selected from the group consisting of N-0923 (rotigotine), levodopa, cabergoline, ropinirole, pergolide and pramipexole.

21. The pharmaceutical composition of claim 1 or 20 wherein the composition consists of (a) the at least one pharmacologically active agent in its solid phase;

(b) the vehicle consisting essentially of polyol fatty acid esters with an esterification level of over 80%; and

(c) the wetting agent comprising polyol fatty acid esters with a monoester content of over 60%.

22. The pharmaceutical composition of claim 1 or 20 wherein the composition does not contain a fatty acid aluminum salt.

23. A kit comprising:

(a) a pharmaceutical composition of claim 1 or 2; and

(b) an injection device.

24. The pharmaceutical composition of claim 2 wherein the active agent is present at a concentration of from 0.01 to 20% (w/v).

25. The pharmaceutical composition of claim 2 wherein the active agent is present at a concentration of from 0.02 to 5% (w/v).

26. The pharmaceutical composition of claim 2 wherein the active agent is selected from the group consisting of N-0923 (rotigotine), levodopa, cabergoline, ropinirole, pergolide and pramipexole.

27. The pharmaceutical composition of claim 2 wherein the composition consists of(a) the at least one pharmacologically active agent in its solid phase;

(b) the vehicle consisting essentially of polyol fatty acid esters with an esterification level of over 80%; and

(c) the wetting agent comprising polyol fatty acid esters with a monoester content of over 60%.

28. The pharmaceutical composition of claim 2 wherein the composition does not contain a fatty acid aluminum salt.

29. The pharmaceutical composition of claim 1 wherein the active agent is selected from the group consisting of N-0923 (rotigotine), levodopa, cabergoline, ropinirole, pergolide and pramipexole.