Self-referencing biodetection method and patterned bioassays
First Claim
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1. A self-referencing colorimetric resonant optical biosensor comprising:
- (a) one or more liquid-holding vessels comprising a colorimetric resonant optical biosensor as a surface; and
(b) one or more specific binding substances immobilized on a first portion of the colorimetric resonant optical biosenor of each liquid-holding vessel forming a reaction surface, and no specific binding substances immobilized on a second portion of the colorimetric resonant optical biosenor of each liquid-holding vessel forming a reference surface, wherein the biosensor comprises two or more reaction surfaces in each liquid holding vessel and two or more reference surfaces in each liquid holding vessel.
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Abstract
The invention relates to compositions and methods for detecting biomolecular interactions. The detection can occur without the use of labels and can be done in a high-throughput manner. The invention further relates to self-referencing colorimetric resonant optical biosensors and optical devices.
103 Citations
7 Claims
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1. A self-referencing colorimetric resonant optical biosensor comprising:
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(a) one or more liquid-holding vessels comprising a colorimetric resonant optical biosensor as a surface; and (b) one or more specific binding substances immobilized on a first portion of the colorimetric resonant optical biosenor of each liquid-holding vessel forming a reaction surface, and no specific binding substances immobilized on a second portion of the colorimetric resonant optical biosenor of each liquid-holding vessel forming a reference surface, wherein the biosensor comprises two or more reaction surfaces in each liquid holding vessel and two or more reference surfaces in each liquid holding vessel. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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Specification