Stabilized pharmaceutical preparation of gamma-aminobutyric acid derivatives and process for preparing the same
First Claim
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1. A solid pharmaceutical composition comprising:
- (a) a neutral α
amino acid, (b) a compound selected from the group consisting of gabapentin and pregabalin, and (c) optionally, one or more auxiliary agents, wherein the neutral α
-amino acid is one or more selected from the group consisting of;
glycine, phenylglycine, hydroxyphenylglycine, dihydroxyphenylglycine, L-alanine, hydroxy-L-alanine, L-leucine, hydroxy-L-leucine, dihydroxy-L-Leucine, L-norleucine, methylene-L-norleucine, L-ketonorleucine, L-isoleucine, hydroxy-L-isoleucine, dihydroxy-L-isoleucine, L-valine, hydroxy-L-valine, L-isovaline, L-norvaline, hydroxy-L-norvaline, hydroxy-L-ketonorvaline, L-methionine, L-homomethionine, L-ethionine, L-threonine, acetyl-L-threonine, L-tryptophan, hydroxy-L-tryptophan, methyl-L-tryptophan, L-tyrosine, hydroxy-L-tyrosine, methyl-L-tyrosine, bromo-L-tyrosine, dibromo-L-tyrosine, 3,5-diiodo-L-tyrosine, acetyl-L-tyrosine, chloro-L-tyrosine, L-m-tyrosine, L-levodopa, L-methyldopa, L-thyroxine, L-serine, acetyl-L-serine, L-homoserine, acetyl-L-homoserine, ethyl-L-homoserine, propyl-L-homoserine, butyl-L-homoserine, L-cystine, L-homocystine, methyl-L-cysteine, allyl-L-cysteine, propyl-L-cysteine, L-phenylalanine, dihydro-L-phenylalanine, hydroxymethyl-L-phenylalanine, L-aminobutyric acid, L-aminoisobutyric acid, L-ketoaminobutyric acid, dichloro-L-aminobutyric acid, dihydroxy-L-aminobutyric acid, phenyl-L-aminobutyric acid, L-aminovaleric acid, L-aminohydroxyvaleric acid, dihydroxy-L-aminovaleric acid, L-aminoisovaleric acid, L-aminohexanoic acid, methyl-L-aminohexanoic acid, L-aminoheptanoic acid, L-aminooctanoic acid, citrulline, and the D- or DL-forms thereof.
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Abstract
The present invention provides a stabilized pharmaceutical preparation of a 4-amino-3-substituted-butanoic acid derivative which can be obtained by incorporating an amino acid as a stabilizer.
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Citations
5 Claims
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1. A solid pharmaceutical composition comprising:
- (a) a neutral α
amino acid, (b) a compound selected from the group consisting of gabapentin and pregabalin, and (c) optionally, one or more auxiliary agents, wherein the neutral α
-amino acid is one or more selected from the group consisting of;
glycine, phenylglycine, hydroxyphenylglycine, dihydroxyphenylglycine, L-alanine, hydroxy-L-alanine, L-leucine, hydroxy-L-leucine, dihydroxy-L-Leucine, L-norleucine, methylene-L-norleucine, L-ketonorleucine, L-isoleucine, hydroxy-L-isoleucine, dihydroxy-L-isoleucine, L-valine, hydroxy-L-valine, L-isovaline, L-norvaline, hydroxy-L-norvaline, hydroxy-L-ketonorvaline, L-methionine, L-homomethionine, L-ethionine, L-threonine, acetyl-L-threonine, L-tryptophan, hydroxy-L-tryptophan, methyl-L-tryptophan, L-tyrosine, hydroxy-L-tyrosine, methyl-L-tyrosine, bromo-L-tyrosine, dibromo-L-tyrosine, 3,5-diiodo-L-tyrosine, acetyl-L-tyrosine, chloro-L-tyrosine, L-m-tyrosine, L-levodopa, L-methyldopa, L-thyroxine, L-serine, acetyl-L-serine, L-homoserine, acetyl-L-homoserine, ethyl-L-homoserine, propyl-L-homoserine, butyl-L-homoserine, L-cystine, L-homocystine, methyl-L-cysteine, allyl-L-cysteine, propyl-L-cysteine, L-phenylalanine, dihydro-L-phenylalanine, hydroxymethyl-L-phenylalanine, L-aminobutyric acid, L-aminoisobutyric acid, L-ketoaminobutyric acid, dichloro-L-aminobutyric acid, dihydroxy-L-aminobutyric acid, phenyl-L-aminobutyric acid, L-aminovaleric acid, L-aminohydroxyvaleric acid, dihydroxy-L-aminovaleric acid, L-aminoisovaleric acid, L-aminohexanoic acid, methyl-L-aminohexanoic acid, L-aminoheptanoic acid, L-aminooctanoic acid, citrulline, and the D- or DL-forms thereof. - View Dependent Claims (2, 3, 4, 5)
- (a) a neutral α
Specification
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Current AssigneeWarner-Lambert Company LLC (Pfizer Inc.)
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Original AssigneeWarner-Lambert Company LLC (Pfizer Inc.)
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InventorsAomatsu, Akira
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Primary Examiner(s)Kwon, Brian
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Application NumberUS09/674,815Time in Patent Office3,144 DaysField of Search514/561, 514/12, 424/451, 424/497US Class Current514/561CPC Class CodesA61K 31/195 having an amino groupA61K 31/197 the amino and the carboxyl ...A61K 47/183 Amino acids, e.g. glycine, ...A61K 47/20 containing sulfur, e.g. dim...A61K 9/1617 Organic compounds, e.g. pho...A61K 9/2013 Organic compounds, e.g. pho...A61P 25/00 Drugs for disorders of the ...A61P 25/08 Antiepileptics; Anticonvuls...A61P 25/28 for treating neurodegenerat...
