Non-invasive body component concentration measuring apparatus and method of noninvasively measuring a concentration of a body component using the same

• US 7,310,542 B2
• Filed: 01/21/2005
• Issued: 12/18/2007
• Est. Priority Date: 01/20/2004
• Status: Active Grant

• Current Assignee: Samsung Electronics Co. Ltd.
• Original Assignee: Samsung Electronics Co. Ltd.
• Inventors: Jeon, Kye-jin, Lee, Jong-youn, Hwang, In-duk, Park, Kun-kook, Kim, Hye-jeong, Jung, Hye-jin, Choe, Eun-young
• Primary Examiner(s): Winakur, Eric F.
• Assistant Examiner(s): Berhanu, Etsub D
• Application Number:
  US11/038,023
• Publication Number:
  US 20050159658A1
• Time in Patent Office: 1,061 Days
• Field of Search: 600/310, 600/322, 600/334, 600/335
• US Class Current: 600/344
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1491 Heated applicators
• CPC Class Codes: A61B 5/6825 Hand
• CPC Class Codes: A61B 5/6833 Adhesive patches
• CPC Class Codes: A61B 5/6843 Monitoring or controlling sensor contact pressure

Abstract

In a non-invasive body component measuring apparatus for measuring a concentration of a body component in a measuring portion of a living body, and a method of non-invasively measuring the concentration of the body component, the non-invasive body component measuring apparatus includes a light source unit for generating light of a predetermined wavelength and for applying the light onto the measuring portion, a detection unit for detecting light reflected or transmitted by the measuring portion and for converting the detected light into an electrical signal, a signal processing unit for processing the electrical signal, and a body-apparatus interface unit for fixing a periphery of the measuring portion during measurement.

Claims

1. A non-invasive body component measuring apparatus for measuring a concentration of a body component in a measuring portion of a living body, the apparatus comprising:

a light source unit for generating light of a predetermined wavelength;

a spectroscope for dividing the light into a predetermined wavelength band and for applying the light onto the measuring portion;

a detection unit for detecting light reflected or transmitted by the measuring portion and for converting the detected light into an electrical signal;

a signal processing unit for processing the electrical signal; and

a body-apparatus interface unit for fixing a periphery of the measuring portion during measurement, wherein the body-apparatus interface unit includes;

a fixing section for securing the periphery of the measuring portion;

an expanding section for stretching the measuring portion by expanding the fixing section;

a body-light reacting section for compressing the measuring portion into a predetermined thickness, the body-light reacting section having two optical windows for transmitting light; and

a thickness adjusting section for adjusting a distance between the two optical windows.

2. The apparatus as claimed in claim 1, further comprising:

a storage unit for storing the signals processed by the signal processing unit; and

a display unit for displaying the processing result of the signal processing unit,

wherein the spectroscope is sensitive to the body component, the concentration of which is to be measured, and effectively cancels an influence of interfering materials.

3. The apparatus as claimed in claim 1, further comprising a temperature adjusting section for maintaining the measuring portion at a constant temperature.

4. The apparatus as claimed in claim 1, wherein the light of the predetermined wavelength is in a near-infrared spectrum when the body component, the concentration of which is to be measured, is glucose.

5. The apparatus as claimed in claim 1, wherein the fixing section is operable to remove tension around the measuring portion having the predetermined thickness and the expanding section is operable to expand the measuring portion to minimize a restoring force generated in the measuring portion.

6. The apparatus as claimed in claim 1, wherein the fixing section includes a plurality of fixing members capable of fixing at least two positions of the measuring portion and the expanding section expands the measuring portion by expanding the plurality of fixing members.

7. A body-apparatus interface unit of a non-invasive body component measuring apparatus for measuring a concentration of a body component in a measuring portion of a living body, the body-apparatus interface unit comprising:

a fixing section for securing a periphery of the measuring portion;

an expanding section for stretching the measuring portion by expanding the fixing section;

a body-light reacting unit for compressing the measuring portion into a predetermined thickness, the body-light reacting unit having two optical windows for transmitting light; and

a thickness adjusting section for adjusting a thickness of the expanded measuring portion.

8. The body-apparatus interface unit as claimed in claim 7, further comprising a temperature adjusting section for maintaining the measuring portion at a constant temperature.

9. The body-apparatus interface unit as claimed in claim 7, further comprising a support section for facilitating positioning of the measuring portion.

10. The body-apparatus interface unit as claimed in claim 7, wherein the fixing section includes a plurality of fixing members capable of fixing at least two positions of the measuring portion and the expanding section expands the measuring portion by expanding the plurality of fixing members.

11. The body-apparatus interface unit as claimed in claim 7, wherein the fixing section is a disposable fixing device including:

an upper cover having an upper window of a predetermined shape;

a lower cover having a lower window of the predetermined shape; and

a hooking section for securing a periphery of the measuring portion by inserting the periphery of the measuring portion, which is expanded by the expanding section, between the upper cover and the lower cover.

12. The body-apparatus interface unit as claimed in claim 11, wherein either one or both of the upper cover and the lower cover is coated with an adhesive material.

13. A method of non-invasively measuring a concentration of a body component in a measuring portion of a living body, the method comprising:

adjusting a thickness of the measuring portion into a first thickness;

removing tension around the measuring portion having the first thickness;

measuring a first absorption spectrum from the measuring portion having the first thickness;

adjusting the thickness of the measuring portion into a second thickness;

measuring a second absorption spectrum from the measuring portion having the second thickness;

establishing a multivariate statistical model about the body component using the first and second absorption spectra and an actually-measured concentration of the body component; and

estimating the concentration of the body component using a difference absorption spectrum measured from the measuring portion using the statistical model.

14. The method as claimed in claim 13, further comprising maintaining a periphery of the measuring portion having the first thickness at a constant temperature.

15. The method as claimed in claim 13, wherein at least two positions of the measuring portion are fixed prior to removing the tension around the measuring portion.

16. The method as claimed in claim 13, further comprising expanding the measuring portion after removing the tension around the measuring portion.

17. The method as claimed in claim 13, wherein when adjusting the thickness of the measuring portion from the first thickness to the second thickness, a difference in repulsive pressure of the measuring portion is about 0.03 N/mm₂ or less.

18. The method as claimed in claim 13, wherein the multivariate statistical model is established by performing a multi-variational statistical analysis to pairs of difference absorption spectra and actually measured concentrations.

19. The method as claimed in claim 18, wherein the pairs of difference absorption spectra and actually measured concentrations are obtained by repeating operations for each actually measured concentration obtained from direct collection of blood from a specific person.