Method and apparatus for adjustment of sequential biventricular pacing parameters

• US 7,310,554 B2
• Filed: 12/19/2003
• Issued: 12/18/2007
• Est. Priority Date: 01/28/2003
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Kramer, Andrew P., Ding, Jiang
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US10/742,630
• Publication Number:
  US 20040193223A1
• Time in Patent Office: 1,460 Days
• Field of Search: 607/15, 607/18, 607/9, 607/123, 607/25, 607/30, 607/32, 607/59, 607/60
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

A method and system are disclosed for setting the pacing parameters utilized by an implantable cardiac device in delivering cardiac resynchronization therapy. The system may, in different embodiments, be implemented in programming of the implantable device and an external programmer in communication therewith or in the programming of the implantable device by itself. The selection of the pacing parameters is based at least in part upon measurements of intrinsic cardiac conduction parameters. Among the pacing parameters which may be selected in this way are the atrio-ventricular delay interval used in atrial-tracking and AV sequential pacing modes and the biventricular offset interval.

Claims

1. A system for setting one of more pacing parameters used by an implantable cardiac rhythm management device in delivering cardiac resynchronization therapy, comprising:

an implantable cardiac rhythm management device which includes;

an atrial sensing channel for generating electrogram signals corresponding to electrical activity in an atrium;

right and left ventricular sensing channels for generating electrogram signals corresponding to electrical activity in the right and left ventricles, respectively;

right and left ventricular pacing channels for delivering pacing pulses to the right and left ventricles, respectively;

a controller for controlling the output of pacing pulses and interpreting electrogram signals, wherein the controller is programmed to deliver a left ventricular pace and a right ventricular pace separated by a programmed biventricular offset interval in accordance with a demand pacing mode; and

, a telemetry interface;

an external programmer with associated display and input means in communication with the implantable device via the telemetry interface;

wherein the system is programmed to generate signals from which the delay between right ventricular and left ventricular activation during an intrinsic beat, referred to as the Δ

_RL interval, may be measured; and

,

wherein the system is programmed to compute an optimum biventricular offset interval in accordance with a formula which expresses the optimum biventricular offset interval as a function of the measured Δ

_RL interval.

2. The system of claim 1 wherein the system is programmed to measure the Δ

_RL interval from electrogram signals received by the implantable device.

3. The system of claim 1 wherein the controller of the implantable device is programmed to pace the ventricles within a programmable atrio-ventricular delay (AVD) interval after an atrial sense in an atrial-tracking mode or an atrial pace in an AV sequential pacing mode.

4. The system of claim 3 wherein the system is programmed to measure at least one intrinsic atrio-ventricular delay interval from electrogram signals during an intrinsic beat and compute an optimum AVD interval in accordance with a formula which expresses the optimum AVD interval as a function of the measured intrinsic atrio-ventricular delay interval.

5. The system of claim 4 wherein the system is programmed to measure right and left intrinsic atrio-ventricular delay intervals and a duration of ventricular depolarization from electrogram signals and wherein the formula for computing the optimum AVD interval includes a linear combination of the measured right and left intrinsic atrio-ventricular delays and the measured duration of ventricular depolarization.

6. The system of claim 5 wherein the right intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a right ventricular sense designated as AV_R, the left intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and the start of left ventricular depolarization in an electrogram designated as AQ*_L, the duration of ventricular depolarization is measured as the interval from the start of left ventricular depolarization to the end of left ventricular depolarization in an electrogram designated as Q*S*, and the formula for computing the optimum AVD is:

AVD=k₁AV_R+k₂AQ*_L+k₃Q*S*+k₄

where k₁, k₂, k₃, and k₄ are specified coefficients.

7. The system of claim 4 wherein a right intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a right ventricular sense designated as AV_R, a left intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a left ventricular sense designated as AV_L, and the formula for computing the AVD is:

AVD=k₁AV_R+k₂AV_L+k₃

where k₁, k₂, and k₃, are specified coefficients.

8. The system of claim 4 wherein the intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a right ventricular sense designated as AVR, a duration of ventricular depolarization is measured as the interval from the start of left ventricular depolarization to the end of left ventricular depolarization in an electrogram designated as Q*S*, and the formula for computing the optimum AVD is:

AVD=k₁AV_R+k₂Q*S*+k₃

where k₁, k₂, and k₃ are specified coefficients.

9. The system of claim 4 wherein specified coefficients defining a linear combination of the measured intrinsic atrio-ventricular delay interval and the measured duration of ventricular depolarization have been pre-derived from a linear regression analysis of clinical population data relating measured intrinsic atrio-ventricular delay intervals and measured durations of ventricular depolarization to an optimum AVD for delivering cardiac resynchronization therapy as determined by measurement of a cardiac function parameter.

10. The system of claim 4 wherein the system is programmed to automatically set the programmed AVD interval in accordance with the computed optimum AVD interval.

11. The system of claim 4 wherein the system is programmed to recommend to an operator of the external programmer that the programmed AVD interval be set to the computed optimum AVD interval.

12. The system of claim 1 wherein the formula for computing the optimum biventricular offset interval BVO is:

BVO=k₁Δ

_RL)+k₂

where k₁ and k₂ are specified coefficients.

13. The system of claim 12 wherein the specified coefficients defining the relationship between the optimum biventricular offset and the measured Δ

_RL interval have been pre-derived from a linear regression analysis of clinical population data relating measured Δ

_RL intervals to an optimum biventricular offset for delivering cardiac resynchronization therapy as determined by measurement of a cardiac function parameter.

14. The system of claim 12 wherein the formula for computing the optimum biventricular offset interval BVO is:

BVO=−

.333(Δ

_RL)−

20.

15. The system of claim 1 wherein the system is programmed to automatically set the programmed biventricular offset interval in accordance with the computed optimum biventricular offset interval.

16. The system of claim 1 wherein the system is programmed to recommend to an operator of the external programmer that the programmed biventricular offset interval be set to the computed optimum biventricular offset interval.

17. The system of claim 1 wherein the measured Δ

_RL interval represents an average measurement taken over a plurality of intrinsic beats.

18. The system of claim 1 wherein the computed optimum biventricular offset interval is modified in order to maintain a desired tachyarrhythmia rate threshold.

19. A method for computing an optimum biventricular offset interval for delivering biventricular pacing therapy, wherein the biventricular offset interval is the interval between right and left ventricular paces, comprising:

measuring a delay between right ventricular and left ventricular activation during an intrinsic beat, referred to as the Δ

_RL interval; and

,

computing an optimum biventricular offset interval in accordance with a formula which expresses the optimum biventricular offset interval as a function of the measured Δ

_RL interval.

20. The method of claim 19 wherein the formula for computing the optimum biventricular offset interval BVO is:

BVO=k₁(ARL)+k₂

where k₁ and k₂ are specified coefficients defining the relationship between the optimum biventricular offset and the measured Δ

_RL interval which have been pre-derived from a linear regression analysis of clinical population data relating measured Δ

_RL intervals to an optimum biventricular offset for delivering cardiac resynchronization therapy as determined by measurement of a cardiac function parameter.