Encased stent

• US 7,311,727 B2
• Filed: 02/04/2004
• Issued: 12/25/2007
• Est. Priority Date: 02/05/2003
• Status: Expired due to Fees

• Current Assignee: The Board of Trustees of the University of Arkansas (University of Arkansas System)
• Original Assignee: The Board of Trustees of the University of Arkansas (University of Arkansas System)
• Inventors: Mazumder, Mark M., Mehta, Jawahar L., Mazumder, Malay K., Ali, Nawab, Trigwell, Steven, Sharma, Rajesh, De, Samiran
• Primary Examiner(s): Bui, Vy Q.
• Application Number:
  US10/771,647
• Publication Number:
  US 20040225346A1
• Time in Patent Office: 1,420 Days
• Field of Search: 623 14- 148, 606/198, 424/364, 424/411, 426/426, 427 224- 225, 427/489
• US Class Current: 623/1.44
• CPC Class Codes: A61F 2/86 Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2002/0086 for preferentially controlling or promoting the growth of specific types of cells or tissues
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/608 having two or more layers
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 31/005 Ingredients of undetermined constitution or reaction products thereof
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 71/02 Polyalkylene oxides
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

An encased stent that discourages restenosis by having a homogenous endothelial cell lining along the inner wall of the stent. The endothelial cell lining may be coated on the stent before the stent is placed in the artery, or the endothelial cell lining may be grown after placement by several factors that encourage such growth and discourage restenosis. The endothelial cells to coat the stent may be genetically modified to enhance the growth of the endothelial cells into a homogeneous lining. The stent has a continuous lining in the form of a multi-layer polymer coating, including a conducting biocorrosion inhibiting layer and a continuous film of polyurethane coupled by a coupling agent to polyethylene glycol. Various drugs and cell factors may be incorporated into the lining, such as anti-thrombin, anti-inflammatory and anti-coagulant drugs, cell cycle inhibitors, and vascular endothelial growth factors.

Claims

1. An encased stent comprising:

a substantially tubular body comprising a plasma-treated wire mesh; and

an encasing coating, comprising

a first layer of a conducting biocorrosion-inhibiting material on said wire mesh;

a second layer of polyurethane forming a substantially continuous film;

a third layer of polyethylene glycol; and

a coupling agent for coupling said second layer of polyurethane to said third layer of polyethylene glycol.

2. The encased stent of claim 1, wherein said encasing coating comprises at least one therapeutic agent selected from the group consisting of an anti-thrombin drug, an anti-inflammatory drug, an anti-coagulant drug, a cell cycle inhibitor and a vascular endothelial growth factor.

3. The encased stent of claim 1 where said conducting biocorrosion-inhibiting material comprises ligno-pani.

4. The encased stent of claim 1 where said coupling agent is toluene diisocyanate.

5. The encased stent of claim 1, wherein said encasing coating comprises an inner surface and an outer surface, further comprising a layer of endothelial cells on said inner surface.

6. The encased stent of claim 5, wherein said inner surface is plasma-treated.

7. The encased stent of claim 1 further comprising means for producing a substantially smooth encasing coating when the stent is expanded radially.

8. The encased stent of claim 7 wherein said means for producing a substantially smooth encasing coating comprises a plurality of thickened regions of said encasing coating between said wires and a plurality of thin regions of said encasing coating in proximity to said wires.