Control device for the separate collection of blood components in output from a blood centrifugation cell

• US 7,311,849 B2
• Filed: 07/23/2004
• Issued: 12/25/2007
• Est. Priority Date: 09/05/2003
• Status: Expired due to Fees

• Current Assignee: Sorin Group Italia SRL (LivaNova Plc)
• Original Assignee: Sorin Group Italia SRL (LivaNova Plc)
• Inventors: Panzani, Ivo, Romagnoli, Sergio, Rossi, Ivan, Sarti, Stefano
• Primary Examiner(s): DRODGE, JOSEPH W
• Application Number:
  US10/898,720
• Publication Number:
  US 20050054508A1
• Time in Patent Office: 1,250 Days
• Field of Search: 210/94, 210/96.1, 210/512.1, 210/745, 210/787, 494/1, 494/2, 494/10, 494/37, 494/43, 494/45, 356/39, 356/51, 356433-436, 250573-576
• US Class Current: 210/745
• CPC Class Codes: A61M 1/367 Circuit parts not covered by the preceding subgroups of group A61M1/3621
• CPC Class Codes: A61M 1/3696 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: A61M 2205/331 used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
• CPC Class Codes: A61M 2205/3313 used specific wavelengths
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 7/08 Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock artificial tears A61P27/04
• CPC Class Codes: B04B 13/00 Control arrangements specially designed for centrifuges; Programme control of centrifuges control arrangements for feed, charge, or discharge B04B11/00
• CPC Class Codes: B04B 5/0442 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: G01N 15/05 in blood
• CPC Class Codes: G01N 2015/018 Platelets
• CPC Class Codes: G01N 21/3151 using two sources of radiation of different wavelengths G01N21/33 - G01N21/39 take precedence

Abstract

The invention provides a control device for the separate collection of blood components in output from a blood centrifugation cell. The control device comprises: a support which comprises a recess for containing a duct; a visible-light emitter with a corresponding receiver, which are arranged on opposite sides with respect to the recess for containing the duct; an infrared-light emitter with a corresponding receiver, which are arranged on opposite sides with respect to the recess for containing the duct; and a processor to detect signals acquired by the two receivers, to calculate a ratio between the values of the signals, and to send signals to the means suitable to selectively send the fluid conveyed by the duct into separate collection bags, the means being able to change the bag in which the fluid is collected.

Claims

1. A control device for the separate collection of blood components in output from a blood centrifugation cell, the cell being connected by a duct made of soft and light-transparent material to means suitable to send selectively the fluid conveyed by the duct into bags for the separate collection of the individual blood components, wherein the control device comprises:

a support which comprises a recess for containing the duct;

a visible-light emitter with a corresponding receiver, both of which are inserted in a first pair of aligned receptacles formed in the support and are arranged on opposite sides with respect to the recess for containing the duct;

an infrared-light emitter with a corresponding receiver, both of which are inserted in a second pair of aligned receptacles formed in the support and are arranged on opposite sides with respect to the recess for containing the duct; and

a processor to detect signals acquired by the two receivers, to calculate a ratio between the values of the signals, and to send signals to the means suitable to send selectively the fluid conveyed by the duct into bags for the separate collection of the individual blood components,

wherein the visible-light and infrared-light emitters, respectively, are inserted in the receptacles formed in the support on opposite sides with respect to the recess for containing the duct.

2. The device according to claim 1, wherein the processor sends a signal that is suitable first to switch the access of the fluid conveyed by the duct from a plasma collection bag to a platelet connection bag when the signal acquired by the visible-light receiver reaches a value that is typically indicative of the passage of only platelets in the duct, and then sends a signal that is suitable to switch the access of the fluid conveyed by the duct from the platelet collection bag to a red cell collection bag when the ratio between the values of the signals collected by the two receivers reaches a value that is typically indicative of the beginning of the flow of red cells in the duct.

3. The device according to claim 1, wherein the recess for containing the duct comprises a narrower access portion in order to produce uniform conditions for insertion of the duct.

4. The device according to claim 1, wherein the receptacles for the emitters and receivers comprise small holes adjacent to the recess in the support and each emitter and corresponding receiver are positioned along a transverse axis of the recess in the support, so as to avoid problems due to any interference produced by the wall of the duct or by the presence of foam.

5. The device according to claim 1, wherein the second pair of aligned receptacles are formed in the support proximate, with respect to the blood flow, to the receptacles of the first pair.

6. The device according to claim 1, wherein the second pair of aligned receptacles has the same shape as the first pair of aligned receptacles.

7. A method for the separate collection of blood components in output from a blood centrifugation cell comprising:

(i) providing a blood centrifugation cell, the cell being connected by a duct made of soft and light-transparent material to means suitable to send selectively the fluid conveyed by the duct into bags for the separate collection of the individual blood components;

(ii) providing a control device for the separate collection of blood components in output from a blood centrifugation cell, wherein the control device comprises;

a support which comprises a recess for containing the duct;

a visible-light emitter with a corresponding receiver, both of which are inserted in a first pair of aligned receptacles formed in the support and are arranged on opposite sides with respect to the recess for containing the duct;

an infrared-light emitter with a corresponding receiver, both of which are inserted in a second pair of aligned receptacles formed in the support and are arranged on opposite sides with respect to the recess for containing the duct; and

a processor to detect signals acquired by the two receivers, to calculate a ratio between the values of the signals, and to send signals to the means suitable to send selectively the fluid conveyed by the duct into bags for the separate collection of the individual blood components, the means being able to change the bag in which the fluid is collected,

wherein the visible-light and infrared-light emitters, respectively, are inserted in the receptacles formed in the support on opposite sides with respect to the recess for containing the duct;

(iii) introducing blood into the blood centrifugation cell;

(iv) centrifuging the blood; and

(v) removing blood components from the blood centrifugation cell using the control device.

8. The method according to claim 7, wherein the processor sends a signal that is suitable first to switch the access of the fluid conveyed by the duct from a plasma collection bag to a platelet connection bag when the signal acquired by the visible-light receiver reaches a value that is typically indicative of the passage of only platelets in the duct, and then sends a signal that is suitable to switch the access of the fluid conveyed by the duct from the platelet collection bag to a red cell collection bag when the ratio between the values of the signals collected by the two receivers reaches a value that is typically indicative of the beginning of the flow of red cells in the duct.

9. The method according to claim 7, wherein the recess for containing the duct comprises a narrower access portion in order to produce uniform conditions for insertion of the duct.

10. The method according to claim 7, wherein the receptacles for the emitters and receivers comprise small holes adjacent to the recess in the support and each emitter and corresponding receiver are positioned along a transverse axis of the recess in the support, so as to avoid problems due to any interference produced by the wall of the duct or by the presence of foam.

11. The method according to claim 7, wherein the second pair of aligned receptacles are formed in the support proximate, with respect to the blood flow, to the receptacles of the first pair.

12. The method according to claim 7, wherein the second pair of aligned receptacles has the same shape as the first pair of aligned receptacles.