Polyactive/polylactic acid coatings for an implantable device

• US 7,311,980 B1
• Filed: 08/02/2004
• Issued: 12/25/2007
• Est. Priority Date: 08/02/2004
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Hossainy, Syed F. A., Tang, Yiwen, Zhang, Gina
• Primary Examiner(s): Chen, Vivian
• Application Number:
  US10/910,453
• Time in Patent Office: 1,240 Days
• Field of Search: None
• US Class Current: 428/480
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: C08L 71/02 Polyalkylene oxides
• CPC Class Codes: Y10T 428/139 Open-ended, self-supporting conduit, cylinder, or tube-type article
• CPC Class Codes: Y10T 428/1393 Multilayer [continuous layer]
• CPC Class Codes: Y10T 428/29 Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
• CPC Class Codes: Y10T 428/31786 Of polyester [e.g., alkyd, etc.]

Abstract

A polymeric coating for a medical device that comprises poly(lactic acid) and a block copolymer including blocks of poly(ethylene glycol) and poly(butylene terephthalate) is provided.

Claims

1. A coating for an implantable medical device comprising:

a first component including a block copolymer including blocks of poly(ethylene glycol) and poly(butylene terephthalate);

a second component including polylactic acid; and

a third component including a bioactive agent, wherein the first component is coating regions beneath and above the second component.

2. A coating for an implantable medical device comprising:

a first component including a block copolymer including blocks of poly(ethylene glycol) and poly(butylene terephthalate);

a second component including polylactic acid; and

a third component including a bioactive agent,

wherein the medical device comprises a body structure aside from the coating.

3. The coating of claim 2, wherein the polylactic acid is poly(L-lactic acid), poly(D,L-lactic acid) or poly(D-lactic acid).

4. The coating of claim 2, wherein the second and third components are blended and the first component is a coating region over the second and third components.

5. The coating of claim 2, wherein the device is a stent.

6. The coating of claim 2, wherein the first component is an AB, ABA or a BAB block copolymer.

7. A coating for an implantable medical device comprising:

a first component including a block copolymer including blocks of poly(ethylene glycol) and poly(butylene terephthalate);

a second component including polylactic acid; and

a third component including a bioactive agent, wherein the second and third components are blended and the first component is coating regions beneath and over the second and third components.

8. A coating for an implantable medical device comprising:

a first layer including a polylactic acid; and

a second layer of a block copolymer including blocks of poly(ethylene glycol) and poly(butylene terephthalate) supported by the first layer of polylactic acid,

wherein the medical device comprises a body structure aside from the coating.

10. The coating of claim 8, additionally comprising a drug.

11. The coating of claim 8, wherein the polylactic acid is poly(L-lactic acid), poly(D,L-lactic acid) or poly(D-lactic acid).

9. A coating for an implantable medical device comprising:

a first layer including a polylactic acid;

a second layer of a block copolymer including blocks of poly(ethylene glycol) and poly(butylene terephthalate) supported by the first layer of polylactic acid; and

a third layer of a block copolymer including blocks of poly(ethylene glycol) and poly(butylene terephthalate) disposed beneath the first layer of polylactic acid.

12. A coating for an implantable medical device comprising:

a first component including blocks which include poly(ethylene glycol) and blocks which include terephthalate;

a second component including polylactic acid; and

a third component including a bioactive agents

wherein the medical device comprises a body structure aside from the coating.