1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors
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Abstract
The present application describes 1,1-disubstituted cycloalkyl compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
55 Citations
31 Claims
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1. A compound of formula I:
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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2. A compound according to claim 1, wherein:
G is a group of Formula IIa;
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3. A compound according to claim 2, wherein:
G is selected from the group; phenyl;
2,5-bis-aminomethyl-phenyl;
2-amido-4-methoxy-phenyl;
2-amido-5-chloro-phenyl;
2-amido-phenyl;
2-aminomethyl-3-fluoro-phenyl;
2-aminomethyl-3-methoxy-phenyl;
2-aminomethyl-4-fluoro-phenyl;
2-aminomethyl-4-methoxy-phenyl;
2-aminomethyl-5-fluoro-phenyl;
2-aminomethyl-5-methoxy-phenyl;
2-aminomethyl-6-fluoro-phenyl;
2-aminomethyl-phenyl;
2-aminosulfonyl-4-methoxy-phenyl;
2-aminosulfonyl-phenyl;
2-aminomethyl-4-ethyl-phenyl;
2-aminosulfonyl-4-ethyl-phenyl;
2-amido-4-ethyl-phenyl;
2-hydroxy-4-methoxy-phenyl;
2-methylsulfonyl-phenyl;
3-(N,N-dimethylamino)-4-chloro-phenyl;
3-(N,N-dimethylamino)-phenyl;
3-(N-hydroxy-amidino)-phenyl;
3-(N-methoxy-amidino)-phenyl;
3-(N-methylamino)-4-chloro-phenyl;
3-(N-methylamino)-phenyl;
3-amidino-phenyl;
3-amido-6-hydroxy-phenyl;
3-amido-phenyl;
3-amino-4-chloro-phenyl;
3-aminomethyl-phenyl;
3-amino-phenyl;
3-chloro-4-fluoro-phenyl;
3-chloro-phenyl;
3-hydroxy-4-methoxy-phenyl;
4-chloro-3-fluoro-phenyl;
4-chloro-phenyl;
4-ethyl-phenyl;
4-ethyl-2-methylsulfonyl-phenyl;
4-ethyl-2-methoxy-phenyl;
4-methoxy-2-methylsulfonyl-phenyl;
4-methoxy-phenyl;
5-chloro-2-aminosulfonyl-phenyl;
5-chloro-2-methylsulfonyl-phenyl;
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4. A compound according to claim 3, wherein:
G is selected from the group; phenyl;
2-amido-4-methoxy-phenyl;
2-amido-phenyl;
2-aminomethyl-3-fluoro-phenyl;
2-aminomethyl-4-fluoro-phenyl;
2-aminomethyl-4-methoxy-phenyl;
2-aminomethyl-5-fluoro-phenyl;
2-aminomethyl-5-methoxy-phenyl;
2-aminomethyl-6-fluoro-phenyl;
2-aminomethyl-phenyl;
2-aminosulfonyl-4-methoxy-phenyl;
2-aminosulfonyl-phenyl;
2-methylsulfonyl-phenyl;
2-aminomethyl-4-ethyl-phenyl;
2-aminosulfonyl-4-ethyl-phenyl;
2-amido-4-ethyl-phenyl;
3-(N,N-dimethylamino)-4-chloro-phenyl;
3-(N,N-dimethylamino)-phenyl;
3-(N-methylamino)-4-chloro-phenyl;
3-(N-methylamino)-phenyl;
3-amido-phenyl;
3-amino-4-chloro-phenyl;
3-aminomethyl-phenyl;
3-amino-phenyl;
3-chloro-phenyl;
4-chloro-phenyl;
4-ethyl-phenyl;
4-ethyl-2-methylsulfonyl-phenyl;
4-ethyl-2-methoxy-phenyl;
4-methoxy-2-methylsulfonyl-phenyl;
4-methoxy-phenyl;
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5. A compound according to claim 4, wherein:
-G is selected from; 2-amido-4-methoxy-phenyl;
2-amido-phenyl;
2-aminomethyl-3-fluoro-phenyl;
2-aminomethyl-4-fluoro-phenyl;
2-aminomethyl-5-fluoro-phenyl;
2-aminomethyl-6-fluoro-phenyl;
2-aminomethyl-phenyl;
2-aminosulfonyl-4-methoxy-phenyl;
2-aminosulfonyl-phenyl;
3-amido-phenyl;
3-amino-4-chloro-phenyl;
3-aminomethyl-phenyl;
3-chloro-phenyl;
4-chloro-phenyl;
4-ethyl-phenyl;
4-methoxy-phenyl;
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6. A compound according to claim 5, wherein:
-G is selected from;
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7. A compound according to claim 6, wherein:
A-B is selected from;
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8. A compound according to claim 1, wherein the compound is the compound is selected from the group:
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1-(4-methoxyphenyl)-6-(4-{1-[(methylamino)methyl]cyclopropyl}phenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(diethylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(isopropylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(cyclopentylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}cyclopropyl)phenyl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(4-hydroxy-1-piperidinyl)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(4-morpholinylmethyl)cyclopropyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(1-pyrrolidinylcarbonyl)cyclopropyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-N,N-dimethylcyclopropanecarboxamide; 1-(4-methoxyphenyl)-6-(4-{1-[(4-methyl-1-piperazinyl)carbonyl]cyclopropyl}phenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(4-hydroxypiperidine-1-carbonyl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropanecarboxamide; 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropanecarboxylic acid cyclopentylamide; 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-N-(1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide; 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-N-(1H-tetrazol-5-yl)cyclopropanecarboxamide; methyl 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropanecarboxylate; 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropanecarbonitrile; 6-{4-[1-(aminomethyl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)methyl]-N-methylacetamide; N′
-ethyl-N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)methyl]-N-methylurea;N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)methyl]-N-methylmethanesulfonamide; 1-(4-methoxyphenyl)-6-{4-[1-(2-methylimidazol-1-ylmethyl)cyclopropyl]phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(thiazol-2-ylaminomethyl)-cyclopropyl]phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; methyl 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopentanecarboxylate; 1-(4-methoxyphenyl)-6-(4-{1-[(methylamino)methyl]cyclopentyl}phenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(dimethylamino)methyl]cyclopentyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(1-pyrrolidinylmethyl)cyclopentyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}cyclopentyl)phenyl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(4-morpholinylmethyl)cyclopentyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopentyl)methyl]-N-methylacetamide; N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopentyl)methyl]-N-methylmethanesulfonamide; methyl 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclobutanecarboxylate; 1-(4-methoxyphenyl)-6-(4-{1-[(methylamino)methyl]cyclobutyl}phenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(dimethylamino)methyl]cyclobutyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(diethylamino)methyl]cyclobutyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(1-pyrrolidinylmethyl)cyclobutyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}cyclobutyl)phenyl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(4-morpholinylmethyl)cyclobutyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclobutyl)methyl]-N-methylacetamide; N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclobutyl)methyl]-N-methylmethanesulfonamide; 1-{4-[1-(4-Methoxyphenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}cyclohexanecarboxylic acid methyl ester; 1-(4-methoxyphenyl)-6-(4-{1-[(methylamino)methyl]cyclohexyl}phenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(dimethylamino)methyl]cyclohexyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclohexyl)methyl]-N-methylacetamide; N-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclohexyl)methyl]-N-methylmethanesulfonamide; 1-(4-methoxyphenyl)-6-(4-{1-[(methylamino)methyl]cyclopropyl}phenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro 7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(isopropylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(cyclopentylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-3-(methylsulfonyl)-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}cyclopropyl)phenyl]-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(diethylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-3-(methylsulfonyl)-6-{4-[1-(4-morpholinylmethyl)cyclopropyl]phenyl}-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; N-[(1-{4-[1-(4-methoxyphenyl)-3-(methylsulfonyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)methyl]-N-methylacetamide; 3-methanesulfonyl-1-(4-methoxyphenyl)-6-{4-[1-(2-methylimidazol-1-ylmethyl)cyclopropyl]phenyl}-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxyphenyl)-6-{4-[1-(thiazol-2-ylaminomethyl)cyclopropyl]phenyl}-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-(4-{1-[(methylamino)methyl]cyclobutyl}phenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro 7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(dimethylamino)methyl]cyclobutyl}phenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(isopropylamino)methyl]cyclobutyl}phenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-3-(methylsulfonyl)-6-{4-[1-(1-pyrrolidinylmethyl)cyclobutyl]phenyl}-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}cyclobutyl)phenyl]-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[(diethylamino)methyl]cyclobutyl}phenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-3-(methylsulfonyl)-6-{4-[1-(4-morpholinylmethyl)cyclobutyl]phenyl}-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; N-[(1-{4-[1-(4-methoxyphenyl)-3-(methylsulfonyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)methyl]-N-methylacetamide; 1-(4-methoxyphenyl)-6-(4-{1-[(methylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-(4-{1-[(diethylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(4-methoxyphenyl)-7-oxo-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(4-methoxyphenyl)-6-{4-[1-(4-morpholinylmethyl)cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-(4-{1-[(isopropylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-[4-(1-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}cyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(4-methoxyphenyl)-6-(4-{1-[(methylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-(4-{1-[(diethylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-7-oxo-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-(4-{1-[(isopropylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-[4-(1-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}cyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-{4-[1-(4-morpholinylmethyl)cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(3-chlorophenyl)-6-{4-[1-(isopropylamino)methyl)cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-{4-[1-(4-morpholinylmethyl)cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-(4-{1-[(isopropylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-{4-[1-(4-morpholinylmethyl)cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(3-chlorophenyl)-6-(4-{1-[(methylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-(4-{1-[(diethylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-(4-{1-[(diisopropylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-(4-{1-[(cyclopropylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-(4-{1-[(cyclobutylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-7-oxo-6-(4-{1-[(2-oxo-1-pyrrolidinyl)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-[4-(1-{[(2-hydroxyethyl)(methyl)amino]methyl}cyclopropyl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-(4-{1-[2-(dimethylamino)-2-oxoethyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-{4-[1-(methoxymethyl)cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-chlorophenyl)-6-{4-[1-(methoxymethyl)cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(3-chlorophenyl)-6-(4-{1-[(methylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(3-chlorophenyl)-6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(3-chlorophenyl)-6-[4-(1-{[(2-hydroxyethyl)(methyl)amino]methyl}cyclopropyl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-7-oxo-6-(4-{1-[(2-oxo-1-pyrrolidinyl)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; N-[(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)methyl]-N-methylacetamide; 6-(4-{1-[(cyclopropylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-(4-{1-[(cyclobutylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-[4-(1-{[(2-hydroxyethyl)amino]methyl}cyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-[4-(1-{[(2-hydroxyethyl)(methyl)amino]methyl}cyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-(4-{1-[(diisopropylamino)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-[4-(1-{[(2-hydroxyethyl)(methyl)amino]methyl}cyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-{4-[1-(dimethylamino)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-(4-{1-[(2-hydroxyethyl)(methyl)amino]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 2-(1-{4-[1-(4-methoxyphenyl)-3-(methylsulfonyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)-N,N-dimethylacetamide; 6-(4-{1-[2-(dimethylamino)-2-oxoethyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 2-(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)-N,N-dimethylacetamide; 2-(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)acetamide; 2-(1-{4-[1-(3-chlorophenyl)-3-cyano-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)acetamide; 1-(3-chlorophenyl)-6-(4-{1-[2-(dimethylamino)-2-oxoethyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 2-(1-{4-[1-(3-chlorophenyl)-3-(methylsulfonyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)-N,N-dimethylacetamide; 1-(4-methoxyphenyl)-7-oxo-6-(4-{1-[(2-oxo-1-imidazolidinyl)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-7-oxo-6-(4-{1-[(2-oxo-1-piperazinyl)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-7-oxo-6-(4-{1-[(3-oxo-4-morpholinyl)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-7-oxo-6-(4-{1-[(2-oxo-1-piperidinyl)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 2-[(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)oxy]acetamide; 1-[4-{3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl carbamate; 2-(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)acetamide; 2-(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)-N,N-dimethylacetamide; 1-(4-methoxyphenyl)-6-{4-[1-(methylamino)cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-{4-[1-(dimethylamino)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-7-oxo-6-{4-[1-(1,3-thiazol-2-ylamino)cyclopropyl]phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; N-(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)urea; N-(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)-N′
-methylurea;N-(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)-2-methylpropanamide; 6-(4-{1-[(4-hydroxy-1-piperidinyl)methyl]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-(4-{1-[(2-methyl-5,6-dihydro-1(4H)-pyrimidinyl)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-(4-{1-[(2-methyl-4,5-dihydro-1H-imidazol-1-yl)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-{4-[1-(4,5-dihydro-1,3-oxazol-2-ylmethyl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-{4-[1-(4,5-dihydro-1H-imidazol-2-ylmethyl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-(4-{1-[(1-methyl-4,5-dihydro-1H-imidazol-2-yl)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-7-oxo-6-(4-{1-[(1,3-thiazol-2-ylamino)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-(4-{1-[(2-methyl-1H-imidazol-1-yl)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-{4-[1-methyl-1-(2-oxo-1-pyrrolidinyl)ethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(4-methoxyphenyl)-6-{4-[1-methyl-1-(2-oxo-1-piperidinyl)ethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-{4-[1,1-dimethyl-2-(2-oxo-1-piperidinyl)ethyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-{4-[1,1-dimethyl-2-(2-oxo-1-pyrrolidinyl)ethyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-{4-[1,1-dimethyl-2-(3-oxo-4-morpholinyl)ethyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-{4-[1,1-dimethyl-2-(2-oxo-1-piperazinyl)ethyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-{4-[1,1-dimethyl-2-(2-oxotetrahydro-1(2H)-pyrimidinyl)ethyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-{4-[1,1-dimethyl-2-(2-oxodihydro-2H-1,3-oxazin-3(4H)-yl)ethyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-{4-[3-(aminocarbonyl)-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-1-methylethyl methylcarbamate; 1-{4-[3-(aminocarbonyl)-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-1-methylethyl 3-pyrrolidinylcarbamate; 6-{4-[1-ethyl-1-(1-pyrrolidinylmethyl)propyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-(4-{1-[(dimethylamino)methyl]-1-ethylpropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-[3-(aminomethyl)phenyl]-6-{4-[1,1-dimethyl-2-(1-pyrrolidinyl)ethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-[3-(aminomethyl)phenyl]-6-{4-[2-(dimethylamino)-1,1-dimethylethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-[3-(aminocarbonyl)phenyl]-6-{4-[2-(dimethylamino)-1,1-dimethylethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-[3-(aminocarbonyl)phenyl]-6-{4-[1,1-dimethyl-2-(1-pyrrolidinyl)ethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-amino-1,2-benzisoxazol-5-yl)-6-{4-[1,1-dimethyl-2-(1-pyrrolidinyl)ethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-amino-1,2-benzisoxazol-5-yl)-6-{4-[1,1-dimethyl-2-(1-pyrrolidinyl)ethyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(1-amino-7-isoquinolinyl)-6-{4-[1,1-dimethyl-2-(1-pyrrolidinyl)ethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(1-amino-7-isoquinolinyl)-6-{4-[2-(dimethylamino)-1,1-dimethylethyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(1-amino-7-isoquinolinyl)-6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(1-amino-7-isoquinolinyl)-7-oxo-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-amino-1,2-benzisoxazol-5-yl)-7-oxo-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(3-amino-1,2-benzisoxazol-5-yl)-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one; 1-(3-amino-1,2-benzisoxazol-5-yl)-7-oxo-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-[3-(aminomethyl)phenyl]-7-oxo-6-(4-{1-[(2-oxo-1-pyrrolidinyl)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-[4-(1-{[acetyl(methyl)amino]methyl}cyclopropyl)phenyl]-1-[3-(aminomethyl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-[3-(aminocarbonyl)phenyl]-6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 3-[3-cyano-6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl]benzamide; 1-(2,3-dihydro-1H-indol-6-yl)-6-(4-{1-[(dimethylamino)methyl]cyclopropyl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(2,3-dihydro-1H-indol-6-yl)-7-oxo-6-{4-[1-(1-pyrrolidinylmethyl)cyclopropyl]phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(2,3-dihydro-1H-indol-6-yl)-7-oxo-6-(4-{1-[(2-oxo-1-pyrrolidinyl)methyl]cyclopropyl}phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-(4-{1-[(dimethylamino)methyl]cyclobutyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(4-methoxyphenyl)-6-{4-[1-(4-morpholinylmethyl)cyclobutyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(4-methoxyphenyl)-6-{4-[1-(4-morpholinylmethyl)cyclopentyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6-(4-{1-[(dimethylamino)methyl]cyclopentyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 1-(4-methoxyphenyl)-6-{4-[1-(2-oxo-pyrrolidin-1-yl)-cyclopropyl]phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(2-oxo-piperidin-1-yl)-cyclopropyl]phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-[4-(1-methylaminocyclopropyl)-phenyl]-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-dimethylaminocyclopropyl)phenyl]-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; N-(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-cyclopropyl)-N-methyl-acetamide; N-(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-cyclopropyl)-N-methyl-methanesulfonamide; N-(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-cyclopropyl)-N-methyl-2-methylaminoacetamide; 2-dimethylamino-N-(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)-N-methylacetamide; N-(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-cyclopropyl)-N-methyl-2-morpholin-4-yl-acetamide; 6-{4-[1-(1-hydroxyethyl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-acetylcyclopropyl)phenyl]-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(1-hydroxy-1-methyl-ethyl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-methoxymethylcyclopropyl)phenyl]-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(4,5-dihydro-oxazol-2-yl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropanecarboxylic acid 2-amino-ethyl ester; 6-{4-[1-(4,5-dihydro-oxazol-2-yl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1-(4,5-dihydro-1H-imidazol-2-yl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)cyclopropyl]phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(1-methanesulfonyl-4,5-dihydro-1H-imidazol-2-yl)-cyclopropyl]phenyl}-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(1H-imidazol-2-yl)cyclopropyl]phenyl}-1-(4-methoxy-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-{4-[1-(1-methyl-1H-imidazol-2-yl)-cyclopropyl]phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 2-[(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-cyclopropyl)-methyl-amino]-acetamide; 6-(4-{1-[(2-hydroxyethyl)-methylamino]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropanecarboxylic acid methoxy-methyl-amide; 6-[4-(1-hydroxymethylcyclopropyl)phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-acetyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-aminocyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxyphenyl)-6-[4-(1-methylaminocyclopropyl)-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amid; 6-[4-(1-dimethylaminocyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-methylaminomethylcyclopentyl)phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-dimethylaminomethylcyclopentyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-dimethylaminomethylcyclopentyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-[4-(1-[(2-hydroxyethyl)methylaminomethyl]-cyclopentyl)phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-hydroxymethyl-cyclopentyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-(4-{1-[(2-hydroxyethyl)methylamino]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxyphenyl)-6-{4-[1-(methyl-prop-2-ynylamino)-cyclopropyl]phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 3-(1-hydroxyethyl)-1-(4-methoxyphenyl)-6-[4-(1-methylamino-cyclopropyl)phenyl]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-acetyl-1-(4-methoxyphenyl)-6-[4-(1-methylamino-cyclopropyl)phenyl]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxyphenyl)-6-[4-(1-methylaminocyclopropyl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid methylamide; 1-(4-methoxyphenyl)-6-[4-(1-methylaminocyclopropyl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid dimethylamide; 6-[4-(1-aminocyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-[4-(1-methylaminocyclopropyl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-[4-(1-dimethylaminocyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 2-[(1-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropyl)-methylamino]acetamide; 6-(4-{1-[(2-hydroxyethyl)methylamino]cyclopropyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-7-oxo-6-[4-(1-pyrrolidin-1-yl-cyclopropyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester; 1-(4-methoxyphenyl)-7-oxo-6-[4-(1-pyrrolidin-1-yl-cyclopropyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxyphenyl)-7-oxo-6-[4-(1-pyrrolidin-1-yl-cyclopropyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxyphenyl)-6-[4-(1-morpholin-4-yl-cyclopropyl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxyphenyl)-6-[4-(1-morpholin-4-yl-cyclopropyl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-[4-(1-dimethylaminocyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid methylamide; 6-[4-(1-dimethylaminocyclopropyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid dimethylamide; 6-{4-[1-(1,1-dioxo-1λ
6-thiomorpholin-4-yl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide;6-[4-(1-aminocyclopropylmethyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-dimethylaminocyclopropylmethyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(3-chloro-phenyl)-6-{4-[1,1-dimethyl-2-(2-oxo-pyrrolidin-1-yl)-ethyl]-phenyl}-7-oxo-4,5,6,7-tetrahydro-1H pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1,1-dimethyl-2-(2-oxo-pyrrolidin-1-yl)-ethyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxy-phenyl)-6-[4-(1-methyl-1-pyrrolidin-1-ylethyl)-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-dimethylamino-1-methyl-ethyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-methoxymethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-methanesulfonyl-1-methyl-ethyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-(4-{1-[2-(2-oxo-2H-pyridin-1-yl)-ethyl]-cyclopropyl}-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N-methyl-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N,N-dimethyl-acetamide; 1-(4-methoxy-phenyl)-6-{4-[1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-hydroxy-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxy-phenyl)-6-{4-[1-(2-methylamino-ethyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxy-phenyl)-6-{4-[1-(2-pyrrolidin-1-yl-ethyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxy-phenyl)-6-{4-[1-(2-morpholin-4-yl-ethyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxy-phenyl)-6-{4-[1-(2-pyrrolidin-1-yl-acetyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-carbamoylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester; 6-[4-(1-carbamoylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-[4-(1-methylcarbamoylmethyl-cyclopropyl)-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester; 1-(4-methoxy-phenyl)-6-[4-(1-methylcarbamoylmethyl-cyclopropyl)-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-dimethylcarbamoylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester; 6-[4-(1-dimethylcarbamoylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1-(2-hydroxy-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-{4-[1-(2-morpholin-4-yl-ethyl)-cyclopropyl]-phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-7-oxo-6-(4-{1-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-{4-[1-(2-methylamino-ethyl)-cyclopropyl]-phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1-(2-diethylamino-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-7-oxo-6-{4-[1-(2-pyrrolidin-1-yl-ethyl)-cyclopropyl]-phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-(4-{1-[2-(2,5-dimethyl-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-(4-{1-[2-(3-hydroxy-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-(4-{1-[2-(2,5-dimethyl-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-7-oxo-6-(4-{1-[2-(2-oxo-piperidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-7-oxo-6-(4-{1-[2-(2-oxo-2H-pyridin-1-yl)-ethyl]-cyclopropyl}-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-(4-{1-[2-(methyl-thiazol-2-yl-amino)-ethyl]-cyclopropyl}-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-{2-[(2-hydroxy-ethyl)-methyl-amino]-ethyl}-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-(4-{1-[2-(2-methyl-imidazol-1-yl)-ethyl]-cyclopropyl}-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-(4-{1-[2-(2,6-dimethyl-piperidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N,N-dimethyl-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N-methyl-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N,N-dimethyl-acetamide; 6-{4-[1-(2-hydroxy-ethyl)-cyclopropyl]-phenyl}-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-6-{4-[1-(2-methoxy-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxy-phenyl)-6-{4-[1-(2-methylamino-ethyl)-cyclopropyl]-phenyl}-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-diethylamino-ethyl)-cyclopropyl]-phenyl}-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-isopropylamino-ethyl)-cyclopropyl]-phenyl}-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxy-phenyl)-6-{4-[1-(2-pyrrolidin-1-yl-ethyl)-cyclopropyl]-phenyl}-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxy-phenyl)-6-(4-{1-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[2-(2,5-dimethyl-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-(4-{1-[2-(3-hydroxy-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxy-phenyl)-6-(4-{1-[2-(2-oxo-piperidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxy-phenyl)-6-{4-[1-(2-morpholin-4-yl-ethyl)-cyclopropyl]-phenyl}-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-{2-[(2-hydroxy-ethyl)-methyl-amino]-ethyl}-cyclopropyl)-phenyl]-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 2-{[2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-ethyl]-methyl-amino}-acetamide; 2-[2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-ethylamino]-acetamide; 6-(4-{1-[2-(2-hydroxy-ethylamino)-ethyl]-cyclopropyl}-phenyl)-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxy-phenyl)-6-(4-{1-[2-(2-methyl-imidazol-1-yl)-ethyl]-cyclopropyl}-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxy-phenyl)-6-(4-{1-[2-(thiazol-2-ylamino)-ethyl]-cyclopropyl}-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 3-methanesulfonyl-1-(4-methoxy-phenyl)-6-(4-{1-[2-(2-oxo-2H-pyridin-1-yl)-ethyl]-cyclopropyl}-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-acetamide; 2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N-methyl-acetamide; 2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N,N-dimethyl-acetamide; 6-{4-[1-(2-hydroxy-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxy-phenyl)-6-{4-[1-(2-methylamino-ethyl)-cyclopropyl]-phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxy-phenyl)-7-oxo-6-{4-[1-(2-pyrrolidin-1-yl-ethyl)-cyclopropyl]-phenyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxy-phenyl)-6-{4-[1-(2-morpholin-4-yl-ethyl)-cyclopropyl]-phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-(4-{1-[2-(1,1-dioxo-116-thiomorpholin-4-yl)-ethyl]-cyclopropyl}-phenyl)-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-(4-{1-[2-(2-hydroxy-ethylamino)-ethyl]-cyclopropyl}-phenyl)-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 2-[2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-ethylamino]-acetamide; 2-{[2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-ethyl]-methyl-amino}-acetamide; 6-[4-(1-{2-[(2-hydroxy-ethyl)-methyl-amino]-ethyl}-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; N-[2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-ethyl]-N-methyl-methanesulfonamide; N-[2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-ethyl]-N-methyl-acetamide; 1-(4-methoxy-phenyl)-7-oxo-6-(4-{1-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-cyclopropyl}-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 1-(4-methoxy-phenyl)-7-oxo-6-(4-{1-[2-(2-oxo-2H-pyridin-1-yl)-ethyl]-cyclopropyl}-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-3-methyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclobutyl]-phenyl}-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclobutyl]-phenyl}-1-(4-methoxy-phenyl)-3-methyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclobutyl]-phenyl}-1-(4-methoxy-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclobutyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-{4-[1-(2-dimethylamino-ethyl)-cyclobutyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1-(2-dimethylamino-ethyl)-cyclobutyl]-phenyl}-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopentyl]-phenyl}-3-methanesulfonyl-1-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopentyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopentyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopentyl]-phenyl}-1-(4-methoxy-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopentyl]-phenyl}-1-(4-methoxy-phenyl)-3-methyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopentyl)-acetamide; 6-[4-(1-carbamoylmethyl-cyclopentyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-[4-(1-methylcarbamoylmethyl-cyclopentyl)-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-dimethylcarbamoylmethyl-cyclopentyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopentyl)-N,N-dimethyl-acetamide; 2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopentyl)-N-methyl-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopentyl)-N-methyl-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopentyl)-N,N-dimethyl-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopentyl)-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-N-methyl-acetamide; 2-(1-{4-[3-methanesulfonyl-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-N,N-dimethyl-acetamide; 2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-N,N-dimethyl-acetamide; 2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-N-methyl-acetamide; 2-(1-{4-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-N-methyl-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-3-methyl-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-N-methyl-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-3-methyl-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-N-methyl-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclobutyl)-N,N-dimethyl-acetamide; (1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-acetic acid; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N-methyl-acetamide; 2-(1-{4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-phenyl}-cyclopropyl)-N,N-dimethyl-acetamide; 1-(4-methoxy-phenyl)-6-{4-[1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-hydroxy-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxy-phenyl)-6-{4-[1-(2-methylamino-ethyl)cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-{4-[1-(2-dimethylamino-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxy-phenyl)-6-{4-[1-(2-pyrrolidin-1-yl-ethyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 1-(4-methoxy-phenyl)-6-{4-[1-(2-morpholin-4-yl-ethyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one 1-(4-methoxy-phenyl)-6-{4-[1-(2-pyrrolidin-1-yl-acetyl)-cyclopropyl]-phenyl}-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one; 6-[4-(1-carbamoylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester; 6-[4-(1-carbamoylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-[4-(1-methylcarbamoylmethyl-cyclopropyl)-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester; 1-(4-Methoxy-phenyl)-6-[4-(1-methylcarbamoylmethyl-cyclopropyl)-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-[4-(1-dimethylcarbamoylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester; 6-[4-(1-dimethylcarbamoylmethyl-cyclopropyl)-phenyl]-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 6-{4-[1-(2-hydroxy-ethyl)-cyclopropyl]-phenyl}-1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-methoxy-phenyl)-6-{4-[1-(2-morpholin-4-yl-ethyl)-cyclopropyl]-phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; and
,1-(4-methoxy-phenyl)-6-{4-[1-(2-morpholin-4-yl-ethyl)-cyclopropyl]-phenyl}-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile; or a pharmaceutically acceptable salt form thereof.
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9. A pharmaceutical composition, comprising:
- a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.
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10. A pharmaceutical composition, comprising:
- a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 2 or a pharmaceutically acceptable salt thereof.
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11. A pharmaceutical composition, comprising:
- a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 3 or a pharmaceutically acceptable salt thereof.
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12. A pharmaceutical composition, comprising:
- a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 4 or a pharmaceutically acceptable salt thereof.
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13. A pharmaceutical composition, comprising:
- a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 5 or a pharmaceutically acceptable salt thereof.
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14. A pharmaceutical composition, comprising:
- a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 6 or a pharmaceutically acceptable salt thereof.
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15. A pharmaceutical composition, comprising:
- a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 7 or a pharmaceutically acceptable salt thereof.
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16. A pharmaceutical composition, comprising:
- a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 8 or a pharmaceutically acceptable salt thereof.
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17. A pharmaceutical composition, comprising:
- a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 6 or a pharmaceutically acceptable salt thereof.
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18. A phatmaceutical composition, comprising:
- a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 7 or a pharmaceutically acceptable salt thereof.
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19. A pharmaceutical composition, comprising:
- a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 8 or a pharmaceutically acceptable salt thereof.
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20. A method for treating a thromboembolic disorder, comprising:
- administering to a patient in need thereof a therapeutically effective amount of a compound of claim 2 or a pharmaceutically acceptable salt form thereof.
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21. A method according to claim 20 wherein the thromboembolic disorder is selected from the group consisting of arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, and thromboembolic disorders in the chambers of the heart.
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22. A method according to claim 20 wherein the thromboembolic disorder is selected from unstable angina, an acute coronary syndrome, first myocardial infarction, recurrent myocardial infarction, ischemic sudden death, transient ischemic attack, stroke, atherosclerosis, peripheral occlusive arterial disease, venous thrombosis, deep vein thrombosis, thrombophlebitis, arterial embolism, coronary arterial thrombosis, cerebral arterial thrombosis, cerebral embolism, kidney embolism, pulmonary embolism, and thrombosis resulting from (a) prosthetic valves or other implants, (b) indwelling catheters, (c) stents, (d) cardiopulmonary bypass, (e) hemodialysis, or (f) other procedures in which blood is exposed to an artificial surface that promotes thrombosis.
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23. A method for treating a thromboembolic disorder, comprising:
- administering to a patient in need thereof a therapeutically effective amount of a compound of claim 4 or a pharmaceutically acceptable salt form thereof.
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24. A method according to claim 23 wherein the thromboembolic disorder is selected from the group consisting of arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, and thromboembolic disorders in the chambers of the heart.
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25. A method according to claim 23 wherein the thromboembolic disorder is selected from unstable angina, an acute coronary syndrome, first myocardial infarction, recurrent myocardial infarction, ischemic sudden death, transient ischemic attack, stroke, atherosclerosis, peripheral occlusive arterial disease, venous thrombosis, deep vein thrombosis, thrombophlebitis, arterial embolism, coronary arterial thrombosis, cerebral arterial thrombosis, cerebral embolism, kidney embolism, pulmonary embolism, and thrombosis resulting from (a) prosthetic valves or other implants, (b) indwelling catheters, (c) stents, (d) cardiopulmonary bypass, (e) hemodialysis, or (f) other procedures in which blood is exposed to an artificial surface that promotes thrombosis.
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26. A method for treating a thromboembolic disorder, comprising:
- administering to a patient in need thereof a therapeutically effective amount of a compound of claim 6 or a pharmaceutically acceptable salt form thereof.
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27. A method according to claim 26 wherein the thromboembolic disorder is selected from the group consisting of arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, and thromboembolic disorders in the chambers of the heart.
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28. A method according to claim 26 wherein the thromboembolic disorder is selected from unstable angina, an acute coronary syndrome, first myocardial infarction, recurrent myocardial infarction, ischemic sudden death, transient ischemic attack, stroke, atherosclerosis, peripheral occlusive arterial disease, venous thrombosis, deep vein thrombosis, thrombophlebitis, arterial embolism, coronary arterial thrombosis, cerebral arterial thrombosis, cerebral embolism, kidney embolism, pulmonary embolism, and thrombosis resulting from (a) prosthetic valves or other implants, (b) indwelling catheters, (c) stents, (d) cardiopulmonary bypass, (e) hemodialysis, or (f) other procedures in which blood is exposed to an artificial surface that promotes thrombosis.
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29. A method for treating a thromboembolic disorder, comprising:
- administering to a patient in need thereof a therapeutically effective amount of a compound of claim 8 or a pharmaceutically acceptable salt form thereof.
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30. A method according to claim 29 wherein the thromboembolic disorder is selected from the group consisting of arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, and thromboembolic disorders in the chambers of the heart.
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31. A method according to claim 29 wherein the thromboembolic disorder is selected from unstable angina, an acute coronary syndrome, first myocardial infarction, recurrent myocardial infarction, ischemic sudden death, transient ischemic attack, stroke, atherosclerosis, peripheral occlusive arterial disease, venous thrombosis, deep vein thrombosis, thrombophlebitis, arterial embolism, coronary arterial thrombosis, cerebral arterial thrombosis, cerebral embolism, kidney embolism, pulmonary embolism, and thrombosis resulting from (a) prosthetic valves or other implants, (b) indwelling catheters, (c) stents, (d) cardiopulmonary bypass, (e) hemodialysis, or (f) other procedures in which blood is exposed to an artificial surface that promotes thrombosis.
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2. A compound according to claim 1, wherein:
Specification
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Current AssigneeBristol-Myers Squibb Company
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Original AssigneeBristol-Myers Squibb Company
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InventorsQiao, Jennifer X., Pinto, Donald J., Orwat, Michael J., Friedrich, Sarah R., Han, Wei
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Primary Examiner(s)Tucker, Zachary C
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Application NumberUS10/430,024Publication NumberTime in Patent Office1,695 DaysField of Search514/225.5, 546/119US Class Current514/230.5CPC Class CodesA61P 7/02 Antithrombotic agents; Anti...C07D 209/30 with hetero atoms or with c...C07D 213/75 Amino or imino radicals, ac...C07D 333/38 Carbon atoms having three b...C07D 401/04 directly linked by a ring-m...C07D 409/12 linked by a chain containin...C07D 471/04 Ortho-condensed systems