Diagnosis of body metabolic emergency state
First Claim
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1. Apparatus which monitors in a non-vital organ at least one tissue viability parameter of a body tissue, the apparatus comprising:
- a) a light source for illuminating a first part of said tissue with at least one illuminating radiation via at least one illumination location;
b) a light collector for receiving radiation from a second part of said tissue, the same as or different from the first part, as a result of an interaction between said illuminating radiation and said tissue, the light collector comprising a filter which preferentially admits a range of wavelengths comprising a portion of, but not all of, the fluorescent emission spectrum of NADH or Fp;
c) a correlator adapted for correlating at least a part of said received radiation with said at least one tissue viability parameter; and
d) an analyzer adapted for generating an indication of a degree of body metabolic emergency state based on said correlating;
wherein the at least one tissue viability parameters comprise at least one of NADH or flavoprotein (Fp) concentration, and the received radiation comprises at least one of NADH and Fp fluorescence emitted by said tissue.
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Abstract
An apparatus, system and method are provided for diagnosing the degree of body metabolic emergency state. A non-vital organ with respect to the metabolic emergency state is first chosen. One or more tissue viability parameters including at least one of NADH and Flavoprotein (Fp) concentration are monitored in the non-vital organ, whereupon the degree of body metabolic emergency state may be determined based on the monitored tissue viability parameters.
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Citations
60 Claims
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1. Apparatus which monitors in a non-vital organ at least one tissue viability parameter of a body tissue, the apparatus comprising:
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a) a light source for illuminating a first part of said tissue with at least one illuminating radiation via at least one illumination location; b) a light collector for receiving radiation from a second part of said tissue, the same as or different from the first part, as a result of an interaction between said illuminating radiation and said tissue, the light collector comprising a filter which preferentially admits a range of wavelengths comprising a portion of, but not all of, the fluorescent emission spectrum of NADH or Fp; c) a correlator adapted for correlating at least a part of said received radiation with said at least one tissue viability parameter; and d) an analyzer adapted for generating an indication of a degree of body metabolic emergency state based on said correlating; wherein the at least one tissue viability parameters comprise at least one of NADH or flavoprotein (Fp) concentration, and the received radiation comprises at least one of NADH and Fp fluorescence emitted by said tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 59, 60)
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47. A method for diagnosing a degree of body metabolic emergency state, comprising:
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a) choosing a non-vital organ to monitor; (b) exciting at least one of NADH and Flavoprotein (Fp) fluorescence in tissue of said non-vital organ by radiation in the fluorescent excitation spectrum of at least one of NADH and Fp; (c) monitoring in said non-vital organ at least one tissue viability parameter including at least one of NADH and Flavoprotein (Fp) concentration, by measuring radiation emitted from said excited tissue that passes through a filter that preferentially admits wavelengths in a range comprising a portion of, but not all of, the fluorescent emission spectrum of NADH or Fp; (d) determining the degree of body metabolic emergency state based on said at least one tissue viability parameter monitored in (c); and (e) indicating to a user the degree of body metabolic emergency state, at least when the degree is greater than a threshold. - View Dependent Claims (48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58)
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Specification