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Methods and materials for optimization of electronic transportation and hybridization reactions

  • US 7,314,542 B2
  • Filed: 09/22/2005
  • Issued: 01/01/2008
  • Est. Priority Date: 09/23/2004
  • Status: Active Grant
First Claim
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1. A method for the transport of a nucleic acid to an electrode site comprising the steps of:

  • providing a nucleic acid and a low conductivity, zwitterionic buffer with a reducing agent to an active electronic system comprising an electrode;

    applying current and voltage to the electrode to effect electrophoretic transportation of the nucleic acid towards the electrode; and

    hybridizing the nucleic acid with a probe located at the electrode, whereby the local pH above the electrode is below the pH of the buffer at its isoelectric point.

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