Cardioprotective delta opioid receptor agonists and methods of using same
First Claim
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1. A method of reducing ischemic damage in cardiac tissue in a subject comprising:
- administering to the subject in need thereof an effective amount of a composition comprising a non-analgesic diarylmethylpiperazine compound of the general formula;
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Abstract
The present invention relates to compositions and methods of treatment for cardioprotection through the use of non-peptidic delta opioid receptor agonist compound(s) that mediate cardioprotective effects of ischemic preconditioning. The compounds are used to reduce injury associated with ischemia and reperfusion of cardiac tissue. Further, the compounds may be used in solutions preserving the viability of an isolated organ.
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Citations
18 Claims
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1. A method of reducing ischemic damage in cardiac tissue in a subject comprising:
administering to the subject in need thereof an effective amount of a composition comprising a non-analgesic diarylmethylpiperazine compound of the general formula;
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2. A method of reducing ischemic damage in cardiac tissue in a subject comprising:
- administering to the subject in need thereof an effective amount of a therapeutic composition comprising a non-analgesic diarylmethylpiperazine compound of the formula;
- administering to the subject in need thereof an effective amount of a therapeutic composition comprising a non-analgesic diarylmethylpiperazine compound of the formula;
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3. A method of reducing ischemic damage in cardiac tissue in a mammal, the method comprising:
- administering to the mammal in need thereof an effective amount of a non-analgesic diarylmethylpiperazine compound of the formula;
- View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11)
- administering to the mammal in need thereof an effective amount of a non-analgesic diarylmethylpiperazine compound of the formula;
- 12. A method of treating ischemia and reperfusion injury in cardiac tissue in a mammal comprising administering to the mammal in need thereof an effective amount of a non-analgesic delta opioid receptor agonist of the formula:
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14. A method of effectuating ischemic preconditioning of cardiac tissue in a subject in need thereof, the method comprising:
- administering to the subject an effective amount of a non-analgesic diarylmethylpiperazine compound of the formula;
- View Dependent Claims (15, 16, 17, 18)
- administering to the subject an effective amount of a non-analgesic diarylmethylpiperazine compound of the formula;
Specification