2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds
1 Assignment
0 Petitions
Accused Products
Abstract
Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
30 Citations
56 Claims
- 1. A compound of the formula:
-
22. The compound 8-(2,6-Difluoro-phenyl)-4-(4-fluoro-2-methyl-phenyl)-2-(2-hydroxy-1-hydroxymethyl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one or a pharmaceutically acceptable salt thereof.
-
23. A pharmaceutical composition comprising an effective amount of 8-(2,6-Difluoro-phenyl)-4-(4-fluoro-2-methyl-phenyl)-2-(2-hydroxy-1-hydroxymethyl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent.
- 24. A method of treating a CSBP/RK/p38 kinase mediated disease selected from rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, and inflammatory bowel disease in a mammal in need thereof, which method comprises administering to said mammal an effective amount of 8-(2,6-Difluoro-phenyl)-4-(4-fluoro-2-methyl-phenyl)-2-(2-hydroxy-1-hydroxymethyl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, or a pharmaceutically acceptable salt thereof.
-
25. A method of treating inflammation in a mammal in need thereof, which method comprises administering to said mammal an effective amount of 8-(2,6-Difluoro-phenyl)-4-(4-fluoro-2-methyl-phenyl)-2-(2-hydroxy-1-hydroxymethyl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, or a pharmaceutically acceptable salt thereof.
Specification