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Arrays of optical confinements and uses thereof

  • US 7,315,019 B2
  • Filed: 09/16/2005
  • Issued: 01/01/2008
  • Est. Priority Date: 09/17/2004
  • Status: Active Grant
First Claim
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1. An apparatus comprising:

  • an array of waveguides on a solid support, said array having a fill fraction greater than about 0.0001, wherein said waveguides are suitable for holding a biological reagent, and wherein said waveguides provide an effective observation volume that permits observation of individual molecules present in said biological reagent; and

    an optical system operatively coupled to the waveguides that detects signals from the effective observation volume of said waveguides.

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