Method and apparatus for non-invasive analysis of blood glucose

• US 7,316,649 B2
• Filed: 04/12/2004
• Issued: 01/08/2008
• Est. Priority Date: 12/28/1999
• Status: Expired due to Fees

• Current Assignee: RF Science & Technology, Inc.
• Original Assignee: Pindi Products, Inc.
• Inventors: Fuller, Milton E.
• Primary Examiner(s): Nasser; Robert L.
• Assistant Examiner(s): Natnithithadha; Navin
• Application Number:
  US10/823,017
• Publication Number:
  US 20040193031A1
• Time in Patent Office: 1,366 Days
• Field of Search: 600/300, 600/309, 600/365, 600/407, 600/409, 600/410, 600/9, 600/10, 600/345, 600/347, 335/302, 335/306, 335/209, 340/854.6, 361/182, 361/482, 607/101
• US Class Current: 600/365
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips
• CPC Class Codes: H01F 7/0273 Magnetic circuits with PM for magnetic field generation

Abstract

An apparatus for non-invasive detection and quantitation of analytes in a sample, such as blood glucose employs a novel amplifier that uses high-gauss permanent magnets to permit an Rf signal to be transmitted through the sample. The concentration of the analyte can be determined from the magnitude of the reduction in the amplitude of the Rf signal at a characteristic frequency.

Claims

1. An apparatus for determining a characteristic of a sample, which comprises:

a base;

a sample receiver supported by the base;

a pair of nodes, including a first node and a second node, positioned at spaced apart locations in the sample receiver and operative to contact the sample when the sample is positioned in the sample receiver;

a source that generates an Rf signal having a selected frequency spectrum that is coupled to said pair of nodes and transmitted from the first node through the sample for detection by the second node;

an analyzer coupled to the pair of nodes that analyzes the Rf signal transmitted through the sample and detected by the second node to determine the characteristic of the sample; and

a pair of magnets that improves the Rf signal transmitted by the first node through the sample to the second node, one of the magnets being positioned adjacent the first node, the other of the magnets being positioned adjacent the second node.

2. The apparatus as claimed in claim 1, wherein the sample is a human digit and wherein the sample receiver is sized to receive the human digit in contact with said nodes.

3. The apparatus as claimed in claim 2, wherein said human digit is a finger.

4. The apparatus as claimed in claim 1, including a magnetically permeable and electrically insulating barrier disposed between one of the magnets and the first node and the other of the magnets and the second node to prevent contact therebetween.

5. The apparatus as claimed in claim 1, wherein each node comprises an electrically conductive plate.

6. The apparatus as claimed in claim 1, wherein the analyzer detects a change in a magnitude of at least one characteristic frequency within the selected frequency spectrum to determine the characteristic of the sample.

7. The apparatus as claimed in claim 1, wherein the pair of magnets are permanent magnets that generate a magnetic field surrounding at least the pair of nodes and at least a portion of the sample when positioned within the sample receiver for analysis.

8. The apparatus as claimed in claim 1, wherein the analyzer detects a change in a magnitude of the Rf signal at a specific frequency within the selected frequency spectrum to determine the characteristic of the sample, the specific frequency corresponding to a biological molecule within the sample, the characteristic corresponding to presence of the biological molecule, the change in the magnitude corresponding to the concentration of the biological molecule within the sample.

9. The apparatus as claimed in claim 1, wherein the characteristic is an analyte concentration.

10. The apparatus as claimed in claim 9, wherein the analyte includes a biological molecule.

11. The apparatus as claimed in claim 9, wherein the analyte comprises glucose.

12. The apparatus as claimed in claim 9, wherein the analyte comprises a protein.

13. The apparatus as claimed in claim 9, wherein the analyte comprises hemoglobin A1c.

14. The apparatus as claimed in claim 9, wherein the analyte comprises a virus.

15. The apparatus as claimed in claim 9, wherein the analyte comprises an enzyme.

16. The apparatus as claimed in claim 9, wherein the analyte comprises cholesterol.

17. A method for detecting a characteristic of a sample, comprising:

(a) providing an apparatus comprising (i) a base;

(ii) a sample receiver supported by the base, (iii) a pair of nodes, including a first node and a second node, positioned at spaced apart locations in the sample receiver and operative to contact the sample when the sample is positioned in the sample receiver, (iv) a source that generates an Rf signal having a selected frequency spectrum that is coupled to said pair of nodes and transmitted from the first node through the sample for detection by the second node, (v) an analyzer coupled to the pair of nodes that analyzes the Rf signal transmitted through the sample and detected by the second node to determine the characteristic of the sample, and (vi) a pair of high gauss permanent magnets that improves the Rf signal transmitted by the first node through the sample to the second node, one of the magnets being positioned adjacent the first node, the other of the magnets being positioned adjacent the second node;

(b) receiving the sample in the sample receiver such that the sample is in contact with the first node and the second node; and

(c) analyzing a change in the Rf signal transmitted by the first node through the sample to the second node to determine the characteristic of the sample.

18. The method as claimed in claim 17, wherein the change is a change in a magnitude of at least one characteristic frequency within the selected frequency spectrum.

19. The method as claimed in claim 18, wherein the characteristic is a presence of a molecule in the sample.

20. The method as claimed in claim 18, wherein the characteristic is a concentration of a molecule in the sample.