Optimized Fc variants
First Claim
Patent Images
1. An antibody or an immunoadhesin of a parent Fc polypeptide, said antibody or immunoadhesin comprising an amino acid modification at position 332 in the Fc region of said parent Fc polypeptide, wherein said antibody or immunoadhesin exhibits altered binding to an Fcγ
- R as compared to said parent Fc polypeptide, wherein numbering is according to the EU index.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
588 Citations
1 Claim
-
1. An antibody or an immunoadhesin of a parent Fc polypeptide, said antibody or immunoadhesin comprising an amino acid modification at position 332 in the Fc region of said parent Fc polypeptide, wherein said antibody or immunoadhesin exhibits altered binding to an Fcγ
- R as compared to said parent Fc polypeptide, wherein numbering is according to the EU index.
Specification