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Method of adapting in-vitro models to aid in noninvasive glucose determination

  • US 7,317,938 B2
  • Filed: 10/29/2004
  • Issued: 01/08/2008
  • Est. Priority Date: 10/08/1999
  • Status: Expired due to Fees
First Claim
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1. A computer implemented method for noninvasively estimating an analyte concentration with an in-vivo instrument system, comprising the steps of:

  • providing a first model;

    removing at least one interference from said first model to form a second model;

    standardizing said in-vivo instrument system to said second model to generate a third model;

    providing an in-vivo test set, comprising;

    at least one in-vivo test signal; and

    a reference analyte concentration corresponding with said in-vivo test signal;

    applying said third model to said in-vivo test signal to generate a test value;

    applying a correction to said third model using said test value and said reference analyte concentration to yield a corrected third model;

    providing an in-vivo measurement signal; and

    estimating and providing for use said analyte concentration using said corrected third model and said in-vivo measurement signal.

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