Farnesoid X receptor agonists
1 Assignment
0 Petitions
Accused Products
Abstract
The invention relates to a compound of formula (I):
wherein all variables are as defined herein and to pharmaceutical compositions, methods of using, and processes for preparing the same.
-
Citations
23 Claims
- 1. A compound of formula (I):
-
21. A compound selected from:
-
3-{[(4-{[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylphenyl)-(methyl)amino]methyl}benzoic acid; Methyl 4-[(4-{[3-(2,6-dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy}-2-dimethylanilino)methyl]benzoate; 3-{[(2-Chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-phenyl)amino]methyl}benzoic acid; 5-[(4-{[3-(2,6-Dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy}-2-dimethyl-anilino)methyl]-2-furoic acid; 4-[(4-{[3-(2,6-Dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy}-2-dimethyl-anilino)methyl]benzoic acid; Methyl 2-[(4-{[3-(2,6-dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy}-2-dimethylanilino)methyl]-3-furoate; N-(2,1,3-Benzoxadiazol-5-ylmethyl)-4-{[3-(2,6-dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy}-N,2-dimethylaniline; N-(4-{[3-(2,6-Dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy}-2-methylphenyl)-N-methyl-N-[4-(1, 2,3-thiadiazol-4-yl)benzyl]amine; 4-[(4-{[3-(2,6-Dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy}-2-dimethyl-anilino)methyl]benzonitrile; 2-[(4-{[3-(2,6-Dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy}-2-dimethyl-anilino)methyl]-3-furoic acid; {3-[(4-{[3-(2,6-Dichlorophenyl)-5-isopropyl4-isoxazolyl]methoxy}-2-dimethylanilino)methyl]phenyl}methanol; {4-[(4-{[3-(2,6-Dichlorophenyl)-5-isopropyl4-isoxazolyl]methoxy}-2-dimethylanilino)methyl]phenyl}methanol; 3-[(4-{[3-(2, 6-Dichlorobenzyl)-5-ethyl4-isoxazolyl]methoxy}-2-dimethylanilino)methyl]benzoic acid; 3-([(4-{[5-Isopropyl-3-(2,4,6-trichlorophenyl)isoxazol-4-yl]methoxy}-2-methylphenyl)-(methyl)amino]methyl}benzoic acid; 3-[(4-{[3-(2, 6-Dichlorobenzyl)-5-isopropyl-4-isoxazolyl]methoxy}-2-dimethylanilino)methyl]benzoic acid; 3-{[(4-{[3-(2-Chlorobenzyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylphenyl)-(methyl)-amino]methyl}benzoic acid; 3-[(4-([5-Cyclopropyl-3-(2,6-dichlorobenzyl)-4-isoxazolyl]methoxy}-2-dimethylanilino)methyl]benzoic acid; 5-{[4-({5-Isopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl}methoxy)-2-dimethylanilino]methyl}-2-furoic acid; 14-{[4-({5-Isopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl}methoxy)-2-dimethylanilino]methyl}benzoic acid; 3-{[4-({5-Isopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl}methoxy)-2-dimethylanilino]methyl}benzoic acid; Methyl 5-{[4-({5-isopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl}methoxy)-2-dimethylanilino]methyl}-2-furoate; Methyl 4-{[4-({5-isopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl4methoxy)-2-dimethylanilino]methyl}benzoate; 4-{[(2-Chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)-amino]carbonyl}benzoic acid; Methyl 3-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy}-anilino)carbonyl]benzoate; Methyl 4-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy}-anilino)carbonyl]benzoate; 3-[(4-{[3-(2,6-Dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy}-2-methylanilino)-carbonyl]benzoic acid; 4-[(4-{[3-(2,6-Dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy}-2-methylanilino)-carbonyl]benzoic acid; 3-[(2-Chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy}-anilino)carbonyl]benzoic acid; 3-[(4-{[3-(2,6-Dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy}-2-dimethylanilino)carbonyl]benzoic acid; 3-[(2-Chloro-4-{[3-(2, 6-dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy}-methylanilino)carbonyl]benzoic acid; 4-[(2-Chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy}-methylanilino)carbonyl]benzoic acid; 3-{[4-({5-Isopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl}methoxy)-2-dimethylanilino]carbonyl}benzoic acid; 3-{[4-({5-Isopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl}methoxy)-2-methylanilino]carbonyl}benzoic acid; 3-{[2-Chloro-4-({5-isopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl}-methoxy)methylanilino]carbonyl}benzoic acid; Methyl 3-{[(4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylphenyl)(methyl)amino]sulfonyl}benzoate; Methyl 3-{[(2-chloro-4-{[3-(2, 6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-phenyl)amino]sulfonyl}benzoate; Methyl 3-{[(4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylphenyl)amino]sulfonyl}benzoate; Methyl 3-{[(4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)-amino]-sulfonyl}benzoate; 3-{[(4-{[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylphenyl)-amino]sulfonyl}benzoic acid; 3-{[(4-{[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxyphenyl)amino]-sulfonyl}benzoic acid; Methyl 3-{[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-phenyl)(methyl)amino]sulfonyl}benzoate; Methyl 3-{[(4-{([3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)-(methyl)amino]sulfonyl}benzoate; Methyl 3-{[(2-chloro-4-{([3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-phenyl)(ethyl)amino]sulfonyl}benzoate; Methyl 3-{[(4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methyl-phenyl)(ethyl)amino]sulfonyl}benzoate; Methyl 3-{[(4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)-(ethyl)-amino]sulfonyl}benzoate; 3-{[(2-Chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)-amino]sulfonyl}benzoic acid; 3-{[(2-Chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)-(methyl)amino]sulfonyl}benzoic acid; 3-{[(4-{[3-(2, 6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylphenyl)-(methyl)amino]sulfonyl}benzoic acid; 3-{[(4-{[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)(methyl)-amino]sulfonyl}benzoic acid; 3-{[(2-Chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)-(ethyl)amino]sulfonyl}benzoic acid; 3-{[(4-{[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylphenyl)-(ethyl)amino]sulfonyl}benzoic acid; 3-{[(4-{[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)(ethyl)-amino]sulfonyl}benzoic acid; Methyl 4-{[(2-chloro-4-{([3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-phenyl)amino]sulfonyl}benzoate; Methyl 4-{[(4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methyl-phenyl)amino]sulfonyl}benzoate; Methyl 4-{[(4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)-amino]sulfonyl}benzoate; 4-{[(2-Chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)-amino]sulfonyl}benzoic acid; 4-{[(4-{[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylphenyl)-amino]sulfonyl}benzoic acid; 4-{[(4-{[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)amino]-sulfonyl}benzoic acid; Methyl 4-{[(4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methyl-phenyl)(methyl)amino]sulfonyl}benzoate; Methyl 4-{[(4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)-(methyl)amino]sulfonyl}benzoate; Methyl 4-{[(4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)-(ethyl)amino]sulfonyl}benzoate; 4-{[(2-Chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)-(methyl)amino]sulfonyl}benzoic acid; 4-{[(4-{[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylphenyl)-(methyl)amino]sulfonyl}benzoic acid; 4-{[(4-{[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)(methyl)-amino]sulfonyl}benzoic acid; 4-{[(2-Chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)-(ethyl)amino]sulfonyl}benzoic acid; 4-{[(4-{[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylphenyl)-(ethyl)amino]sulfonyl}benzoic acid; 4-{[(4-{[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenyl)(ethyl)amino]-sulfonyl}benzoic acid; 3-({[2-Chloro-4-({5-isopropyl-3-[2-(trifluoromethoxy)phenyl]isoxazol-4-yl}methoxy)-phenyl]amino}sulfonyl)benzoic acid; 3-({[4-({5-Isopropyl-3-[2-(trifluoromethoxy)phenyl]isoxazol-4-yl}methoxy)-2-methyl-phenyl]amino}sulfonyl)benzoic acid; Methyl 3-{[[2-chloro-4-({5-isopropyl-3-[2-(trifluoromethoxy)phenyl]-isoxazol-4-yl}methoxy)phenyl](methyl)amino]sulfonyl}benzoate; Methyl 3-{[[4-({5-isopropyl-3-[2-(trifluoromethoxy)phenyl]isoxazol-4-yl}methoxy)-2-methylphenyl](methyl)amino]sulfonyl}benzoate; 3-{([[2-Chloro-4-({5-isopropyl-3-[2-(trifluoromethoxy)phenyl]isoxazol-4-yl}methoxy)-phenyl](methyl)amino]sulfonyl}benzoic acid; 3-{[[4-({5-Isopropyl-3-[2-(trifluoromethoxy)phenyl]isoxazol-4-yl}methoxy)-2-methyl-phenyl](methyl)amino]sulfonyl}benzoic acid; 3-{[(4-{[3-(2,6-Dichlorobenzyl)-5-ethylisoxazol-4-yl]methoxy}-2-methylphenyl)(methyl)-amino]sulfonyl}benzoic acid; Methyl 4-[(2-chloro-4-[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy)-benzyl)oxy]benzoate; Methyl 3-[(2-chloro-4-{[3-(2, 6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-benzyl)-oxy]benzoate; 3-[(2-Chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-benzyl)oxy]-benzoic acid; 3-[(2-Chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-benzyl)thio]-benzoic acid; 3-[(4-{[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylbenzyl)-oxy]-benzoic acid; 3-[(4-{[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylbenzyl)-thio]-benzoic acid; 4-[(2-Chloro-4-{[3-(2, 6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzyl)-oxy]benzoic acid; 4-[(2-Chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzyl)-thio]-benzoic acid; Methyl 3-{[2-chloro-4-({5-isopropyl-3-[2-(trifluoromethoxy)-phenyl]isoxazol-4-yl}methoxy) benzyl]oxy}benzoate; Methyl 3-{[4-({5-isopropyl-3-[2-(trifluoromethoxy)phenyl]isoxazol-4-yl}methoxy)-2-methylbenzyl]oxy}benzoate; 3-{[2-Chloro-4-({5-isopropyl-3-[2-(trifluoromethoxy)phenyl]isoxazol-4-yl}methoxy)-benzyl]oxy}benzoic acid; 3-{[4-({5-Isopropyl-3-[2-(trifluoromethoxy)phenyl]isoxazol-4-yl}methoxy)-2-methyl-benzyl]oxy}benzoic acid; 3-[(2-Chloro-4-{([3-(2,6-dichlorobenzyl)-5-ethylisoxazol-4-yl]methoxy}benzyl)oxy]-benzoic acid; Methyl 3-{[2-chloro-4-({5-isopropyl-3-[2-(trifluoro-methoxy)phenyl]isoxazol-4-yl}methoxy) benzyl]thio}benzoate; Methyl 3-{[4-({5-isopropyl-3-[2-(trifluoromethoxy)phenyl]isoxazol-4-yl}methoxy)-2-methylbenzyl]thio}benzoate; 3-{[2-Chloro-4-({5-isopropyl-3-[2-(trifluoromethoxy)phenyl]isoxazol-4-yl}methoxy)-benzyl]thio}benzoic acid; 3-{[4-({5-Isopropyl-3-[2-(trifluoromethoxy)phenyl]isoxazol-4-yl}methoxy)-2-methyl-benzyl]thio}benzoic acid; Methyl 3-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzyl)(methyl)amino]benzoate; 3-[(2-Chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzyl)-(methyl)amino]benzoic acid; 3-[(2-Chloro-4-{[3-(2, 6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzyl)-amino]benzoic acid; Ethyl 3-{[2-chloro-4-({5-isopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl}-methoxy)benzyl]amino}benzoate; 3-{[2-Chloro-4-({5-isopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl}methoxy)-benzyl]amino}benzoic acid; 3-[[2-Chloro-4-({5-isopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl}methoxy)-benzyl](methyl)amino]benzoic acid; Methyl 4-[(4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylphenoxy)methyl]benzoate; Methyl 3-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-phenoxy)methyl]benzoate; Methyl 3-[(4-{([3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methyl-phenoxy)methyl]benzoate; 3-[(2-Chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}phenoxy)-methyl]benzoic acid; 3-[(4-{[3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methylphenoxy)-methyl]benzoic acid; and Methyl 4-[(4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}-2-methyl-phenoxy)methyl]benzoate, and pharmaceutically acceptable salts and solvates thereof.
-
-
22. A compound of formula (I):
-
23. A compound of formula (I):
Specification