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Methylenetetrahydrofolate reductase inhibitors and use thereof

  • US 7,319,145 B2
  • Filed: 12/03/2001
  • Issued: 01/15/2008
  • Est. Priority Date: 12/03/2001
  • Status: Expired due to Fees
First Claim
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1. An inhibitor of methylenetetrahydrofolate reductase (MTHFR) that selectively inhibits cancer cell growth in a mammal comprising an antisense oligonucleotide of 20 to about 50 nucleotides in length that is at least 90% identical to the complement of a region of exon 5 of a human MTHFR mRNA and comprises the sequence as set forth in SEQ ID NO:

  • 16, wherein said human MTHFR mRNA has the sequence as set forth in SEQ ID NO;

    1.

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