Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
First Claim
1. A system, comprising:
- an implantable metabolic sensor to sense a metabolic signal indicative of a cardiac metabolic level;
an implantable processor coupled to the implantable metabolic sensor, the implantable processor including;
a metabolic sensor processing circuit to determine the cardiac metabolic level from the metabolic signal; and
a drug delivery controller to produce a drug delivery signal based on the cardiac metabolic level; and
an implantable drug delivery device, communicatively coupled to the implantable processor, to deliver a drug based on the drug delivery signal, the implantable drug delivery device including a drug reservoir storing a drug shifting a source of metabolically synthesized energy for cardiac contractions from fatty acid to glucose.
1 Assignment
0 Petitions
Accused Products
Abstract
A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.
-
Citations
43 Claims
-
1. A system, comprising:
-
an implantable metabolic sensor to sense a metabolic signal indicative of a cardiac metabolic level; an implantable processor coupled to the implantable metabolic sensor, the implantable processor including; a metabolic sensor processing circuit to determine the cardiac metabolic level from the metabolic signal; and a drug delivery controller to produce a drug delivery signal based on the cardiac metabolic level; and an implantable drug delivery device, communicatively coupled to the implantable processor, to deliver a drug based on the drug delivery signal, the implantable drug delivery device including a drug reservoir storing a drug shifting a source of metabolically synthesized energy for cardiac contractions from fatty acid to glucose. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
-
-
21. A method, comprising:
-
sensing a metabolic signal using an implantable sensor; determining a cardiac metabolic level based on the metabolic signal using an implantable processor connected to the implantable sensor; producing a drug delivery signal based on the cardiac metabolic level; and delivering a drug from an implantable drug delivery device, upon receipt of the drug delivery signal, to shift a source of metabolically synthesized energy for cardiac contractions from fatty acid to glucose. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
-
Specification