Apparatus and methods for the delivery of medicaments to the respiratory system

• US 7,322,349 B2
• Filed: 06/18/2003
• Issued: 01/29/2008
• Est. Priority Date: 05/05/2000
• Status: Expired due to Term

• Current Assignee: Novartis Pharma AG (Novartis Ag)
• Original Assignee: Aerogen, Inc. (Nektar Therapeutics)
• Inventors: Power, John S.
• Primary Examiner(s): Douglas; Steven O.
• Application Number:
  US10/465,023
• Publication Number:
  US 20040035490A1
• Time in Patent Office: 1,686 Days
• Field of Search: 128/200.14, 128/200.16, 128/200.18, 128/203.12, 128/202.27, 128/912, 128/200.21, 128/200.26, 239/338, 239/102.1, 239/102.2
• US Class Current: 128/200.14
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 16/0833 T- or Y-type connectors, e.g. Y-piece
• CPC Class Codes: A61M 2209/082 Mounting brackets, arm supports for equipment

Abstract

An apparatus for delivery of a medicament to the respiratory system comprises a reservoir that is adapted to hold a liquid medicament that is to be delivered to a respiratory system. An aerosol generator is provided that is adapted to aerosolize the liquid medicament. A liquid supplier is used to deliver the liquid medicament from the reservoir to the aerosol generator. A connector is operably coupled to the aerosol generator and comprises a gas conduit having an inlet, and an outlet, and an aerosol supply conduit. The aerosol generator is configured to provide the aerosolized liquid medicament into the gas conduit through the aerosol supply conduit, and the gas conduit is adapted to pass gases to entrain the aerosolized liquid medicament.

Claims

1. A nebulizer system comprising:

at least one tubing section having an inlet and an outlet forming an air path for delivering air to a patient from a ventilator;

a nebulizer which is adapted to deliver a nebulized fluid to the tubing section for inhalation by a patient on a ventilator, the nebulizer having a vibrating element having a front side, a back side, and a plurality of tapered apertures extending between the front side and the back side, and wherein the vibrating element separates a source of fluid from the air path;

a feed system adapted to provide fluid to the back side of the vibrating element;

a ring-shaped piezoelectric element comprising a piezoelectric material and configured to vibrate the vibratable element when an electrical current is provided to the ring-shaped piezoelectric element; and

wherein vibration of the vibrating element is adapted to move fluid from the back side of the vibrating element through the plurality of tapered apertures to produce the nebulized fluid which enters the tubing section for delivery to the patient.

2. A nebulizer system as claimed in claim 1, wherein the at least one tubing section includes a T-shaped section.

3. A nebulizer system as claimed in claim 1, wherein the openings in the vibrating element are sized to eject liquid droplets such that about 70% or more of the droplets by weight have a size in the range from about 1 to about 5 micrometers.

4. The nebulizer system recited in claim 1 wherein the inlet has a longitudinal axis coaxial with a longitudinal axis of the outlet.

5. The nebulizer system recited in claim 1 further comprising the ventilator mated with the inlet with the interference fit.

6. The nebulizer system recited in claim 2 wherein the T-shaped section subtends an angle less than 90°

with an inlet side of the at least one tubing section.

7. The nebulizer system recited in claim 6 wherein the at least one tubing section tapers outwardly from the inlet to the outlet.

8. A nebulizer system comprising:

a ventilator;

a tubing section having an inlet and an outlet forming an air path for delivering air to a patient from the ventilator, wherein;

a longitudinal axis of the inlet is coaxial with a longitudinal axis of the outlet; and

the tubing section comprises a T-shaped section having an aerosol inlet such that the longitudinal axis of the inlet subtends an angle less than 90°

with a longitudinal axis of the aerosol inlet;

a nebulizer adapted to deliver a nebulized fluid to the tubing section through the aerosol inlet for inhalation by a patient on the ventilator, the nebulizer having a ring-shaped piezoelectric element configured to vibrate a vibrating element having a plurality of openings therein, the vibrating element having a front side and a back side, and wherein the vibrating element separates a source of fluid from the air path,

wherein;

the ring-shaped piezoelectric element comprises a piezoelectric material;

the ring-shaped piezoelectric element is configured to vibrate the vibrating element when an electrical current is provided to the ring-shaped piezoelectric element;

vibration of the vibrating element is adapted to move fluid from the back side of the vibrating element through the plurality of openings to produce the nebulized fluid which enters the tubing section for delivery to the patient; and

the tubing section is adapted to entrain the nebulized fluid with air delivered by the ventilator to the patient.